About: Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid‐19

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About: Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid‐19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid‐19
Creator	Smith, Stephen Boppana, Avinash Brufsky, Adam Chao, Kathy Connor, Ruth Dobesh, David Maddock, Daniel Traupman, Julie Unson, Enrique
source	Medline; PMC
abstract	BACKGROUND: Identification of risk factors of severe Covid‐19 is critical for improving therapies and understanding SARS‐CoV‐2 pathogenesis. METHODS: We analyzed 184 patients hospitalized for Covid‐19 in Livingston, New Jersey for clinical characteristics associated with severe disease. RESULTS: The majority of Covid‐19 patients had diabetes mellitus (DM) (62.0%), Pre‐DM (23.9%) with elevated FBG, or a BMI > 30 with normal HbA1C (4.3%). SARS‐CoV‐2 infection was associated with new and persistent hyperglycemia in 29 patients, including several with normal HbA1C levels. Forty‐four patients required intubation, which occurred significantly more often in patients with DM as compared to non‐diabetics. CONCLUSIONS: Severe Covid‐19 occurs in the presence of impaired glucose metabolism in patients, including those with DM, PreDM and obesity. Covid‐19 is asociated with elevated FBG and several patients presented with new onset DM or in DKA. The association of dysregulated glucose metabolism and severe Covid‐19 suggests that SARS‐CoV‐2 pathogenesis involves a novel interplay with glucose metabolism. Exploration of pathways by which SARS‐CoV‐2 interacts glucose metabolism is critical for understanding disease pathogenesis and developing therapies. This article is protected by copyright. All rights reserved.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.1002/jmv.26227
bibo:pmid	32589756
has license	no-cc
sha1sum (hex)	4752ad751b916195e5a3bd0a6f2747e92e7676a3
schema:url	https://doi.org/10.1002/jmv.26227
resource representing a document's title	Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid‐19
has PubMed Central identifier	PMC7361926
has PubMed identifier	32589756
schema:publication	J Med Virol
resource representing a document's body	covid:4752ad751b916195e5a3bd0a6f2747e92e7676a3#body_text
is schema:about of	named entity 'Covid-19' named entity 'Covid' named entity 'diabetes' named entity 'diabetes' named entity 'COVID-19' named entity 'Covid' named entity 'hyperlipidemia' named entity 'HbA1C' named entity 'intubation' named entity 'ICU' named entity 'hypoxia' named entity 'attending physician' named entity 'population proportion' named entity 'triaging' named entity 'Covid' named entity 'Covid-19' named entity 'triage' named entity 'corticosteroids' named entity 'hyperglycemia' named entity 'obesity' named entity 'infection' named entity 'hypertension' named entity 'lung' named entity 'Covid-19' named entity 'hyperglycemia' named entity 'Covid' named entity 'Diabetes' named entity 'obesity' named entity 'Fever' named entity 'end-stage renal disease' named entity 'disproportionately weighted' named entity 'intubated' named entity 'fever' named entity 'fasting blood glucose' named entity 'BMI' named entity 'HbA1C' named entity 'Covid' named entity 'morbidity' named entity 'inflammation' named entity '5.7' named entity 'Covid' named entity 'obese' named entity 'infection' named entity 'Covid' named entity 'coronary artery disease' named entity 'HbA1C' named entity 'SARS' named entity 'HbA1C' named entity 'HbA1C' named entity 'pre-diabetes' named entity 'p-values' named entity 'intubation' named entity 'A1C' named entity 'blood glucose level' named entity 'Italy' named entity 'health conditions' named entity '5.7' named entity 'risk factor' named entity 'Covid' named entity 'HbA1C' named entity 'HbA1C' named entity 'risk factors' named entity 'FBG' named entity 'SARS-CoV-2' named entity 'hyperglycemia' named entity 'Clinical presentation' named entity 'SARS-CoV-2' named entity 'glycemia' named entity 'COVID' named entity 'preexisting conditions' named entity 'Covid' named entity 'diabetes' named entity 'intubated'

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