About: Remarkable enhancement of flavonoid production in a co-cultivation system of Isatis tinctoria L. hairy root cultures and immobilized Aspergillus niger

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About: Remarkable enhancement of flavonoid production in a co-cultivation system of Isatis tinctoria L. hairy root cultures and immobilized Aspergillus niger Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Remarkable enhancement of flavonoid production in a co-cultivation system of Isatis tinctoria L. hairy root cultures and immobilized Aspergillus niger
Creator	Wang, Wei Fu, Yu-Jie Gai, Qing-Yan Jiao, Jiao Wang, Xin Niu, Li-Li Zang, Yu-Ping
source	Elsevier; Medline; PMC
abstract	Abstract The dried roots of Isatis tinctoria L. are highly traded in the pharmaceutical industry due to their notable anti-influenza efficacy. For the first time, I. tinctoria hairy root cultures (ITHRCs) were co-cultured with two immobilized live GRAS (Generally Recognized as Safe) fungi, i.e. Aspergillus niger and Aspergillus niger, for the elevated production of pharmacologically active flavonoids. Immobilized A. niger (IAN) was exhibited as the superior elicitor in the plant-fungus co-cultivation system. The highest flavonoid production (3018.31±48.66μg/g DW) were achieved in IAN-treated ITHRCs under the optimal conditions of IAN spore concentration ca.104 spores/mL, temperature 30°C, initial pH value of media 7.0 and time 72h, which remarkably increased 6.83-fold relative to non-treated control (441.91±7.35μg/g DW). Also, this study revealed that IAN elicitation could trigger the sequentially transient accumulation of signal molecules and intensify the oxidative stress in ITHRCs, which both contributed to the up-regulated expression of associated genes involved in flavonoid biosynthetic pathway. Moreover, IAN could be reused at least five cycles with satisfactory performance. Overall, the coupled culture of IAN and ITHRCs is a promising and effective approach for the enhanced production of flavonoids, which allows for the improved applicability of these valuable compounds in pharmaceutical fields.
has issue date	2018-02-28(xsd:dateTime)
bibo:doi	10.1016/j.indcrop.2017.12.017
bibo:pmid	32288265
has license	els-covid
sha1sum (hex)	47ac0a2946024dc9e39e66af22701e2989e015fa
schema:url	https://doi.org/10.1016/j.indcrop.2017.12.017
resource representing a document's title	Remarkable enhancement of flavonoid production in a co-cultivation system of Isatis tinctoria L. hairy root cultures and immobilized Aspergillus niger
has PubMed Central identifier	PMC7125528
has PubMed identifier	32288265
schema:publication	Industrial Crops and Products
resource representing a document's body	covid:47ac0a2946024dc9e39e66af22701e2989e015fa#body_text
is schema:about of	named entity 'superior' named entity 'A. niger' named entity 'signal molecules' named entity 'I. tinctoria' named entity 'For' named entity 'compounds' named entity 'temperature' named entity 'effective' named entity 'Isatis tinctoria' named entity 'ENHANCEMENT' named entity 'SAFE' named entity 'TRIGGER' named entity 'CULTURES' named entity 'ALLOWS' named entity 'TRANSIENT' named entity 'BCG' named entity 'GENES' named entity 'DRIED' named entity 'PRODUCTION' named entity 'FUNGI' named entity 'CULTURED' named entity 'FLAVONOIDS' named entity 'PHARMACEUTICAL INDUSTRY' named entity 'ROOTS' named entity 'ASSOCIATED' named entity 'CONDITIONS' named entity 'IMPROVED' named entity 'ISATIS TINCTORIA' named entity 'SUPERIOR' named entity 'HIGHLY' named entity 'MEDIA' named entity 'CONTROL' named entity 'FOLD' named entity 'FLAVONOID BIOSYNTHETIC PATHWAY' named entity 'PLANT-' named entity 'ELICITOR' named entity 'EFFECTIVE' named entity 'THESE' named entity 'INVOLVED' named entity 'CULTURE' named entity 'HIGHEST' named entity 'REUSED' named entity 'INCREASED' named entity 'SATISFACTORY' named entity 'PERFORMANCE' named entity 'DUE TO' named entity 'ISATIS TINCTORIA' named entity 'ASPERGILLUS NIGER' named entity 'HAIRY ROOT' named entity 'SYSTEM' named entity 'CONCENTRATION' named entity 'FLAVONOID' named entity 'PRODUCTION' named entity 'CULTURES' named entity 'SYSTEM' named entity 'CULTIVATION' named entity 'HAIRY ROOT' named entity 'INITIAL' named entity 'SPORES' named entity 'OVERALL' named entity '30%' named entity 'TEMPERATURE' named entity 'CULTIVATION' named entity 'ASPERGILLUS NIGER' named entity 'GRAS' named entity 'PHARMACEUTICAL' named entity 'OXIDATIVE STRESS' named entity 'ENHANCED' named entity 'SPORE' named entity 'RELATIVE TO' named entity 'THEIR' named entity 'IS A' named entity 'FUNGUS' named entity 'TIME' named entity 'NOTABLE'

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