About: Epidemiology of Clostridium difficile infection in a large teaching hospital in Singapore

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Epidemiology of Clostridium difficile infection in a large teaching hospital in Singapore Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiology of Clostridium difficile infection in a large teaching hospital in Singapore
Creator	Lee Tan, Mee Wang, Grace Koh, I C R O B I O L O G Y, M Ling Tan, A Peng, Keang Tse, Hsien
Source	Elsevier; Medline; PMC
abstract	Summary Aims We undertook this study to define the incidence of toxigenic Clostridium difficile in our hospital and to characterise the isolates. Methods All unformed stool was tested for the presence of Toxin A (TcdA) and Toxin B (TcdB), and cultured for C. difficile. Culture filtrates were also tested for TcdA and TcdB. Detection of tcdA and tcdB genes was carried out for A2B+ strains by polymerase chain reaction (PCR).The minimum inhibitory concentrations (MICs) of metronidazole, vancomycin and clindamycin for all isolates were tested using the Etest. PCR ribotyping was carried out on all isolates. Results The incidence of Clostridium difficile associated disease (CDAD) was 3.2 cases per 1000 admissions or discharges and 53.8 cases per 100000 patient days. Most cases occurred in renal and haematology patients. CDAD was more common in patients aged over 50 years and of male gender. The Indian population was under-represented. Fourteen (11.8%) isolates were A-B+. All strains were susceptible to metronidazole but one strain showed intermediate resistance to vancomycin. Only 12.8% of the isolates were susceptible to clindamycin. Thirty-five isolates had PCR ribotype A, of which 29 (83%) had a clindamycin MIC >256mg/L. Thirty-three had PCR ribotype B, of which only one (3%) had a clindamycin MIC >256mg/L. The 14 A-B+ strains were all PCR ribotype C, and had a range of MICs for clindamycin from 2 to >256mg/L. Conclusions: The incidence of CDAD in our hospital is relatively low. Isolates remain susceptible to metronidazole and vancomycin.
has issue date	2007-08-31(xsd:dateTime)
bibo:doi	10.1080/00313020701444507
bibo:pmid	17676487
has license	els-covid
sha1sum (hex)	47e593a00576aad5a15d454e14495f971129e9da
schema:url	https://doi.org/10.1080/00313020701444507
resource representing a document's title	Epidemiology of Clostridium difficile infection in a large teaching hospital in Singapore
has PubMed Central identifier	PMC7130798
has PubMed identifier	17676487
schema:publication	Pathology
resource representing a document's body	covid:47e593a00576aad5a15d454e14495f971129e9da#body_text
is schema:about of	named entity 'EPIDEMIOLOGY' named entity 'cases' named entity 'patients' named entity 'male' named entity 'intermediate' named entity 'All' named entity 'presence' named entity 'metronidazole' named entity 'Epidemiology' named entity 'large' named entity 'SINGAPORE' named entity 'YEARS' named entity 'RANGE' named entity 'INCIDENCE' named entity 'TESTED FOR' named entity 'HOSPITAL' named entity 'DAYS' named entity 'INHIBITORY' named entity 'CULTURED' named entity 'USING' named entity 'PRESENCE OF TOXIN' named entity 'THIRTY' named entity 'VANCOMYCIN' named entity 'TESTED' named entity 'TCDB' named entity 'RESISTANCE TO VANCOMYCIN' named entity 'STOOL' named entity 'RIBOTYPING' covid:arg/47e593a00576aad5a15d454e14495f971129e9da named entity 'MIC' named entity 'AIMS' named entity '283' named entity '12.8' named entity 'BUT' named entity 'POLYMERASE CHAIN REACTION' named entity 'TOXIN B' named entity 'TCDA' named entity 'PCR' named entity 'ASSOCIATED' named entity 'ADMISSIONS' named entity 'CLOSTRIDIUM DIFFICILE INFECTION' named entity 'FOURTEEN' named entity 'CDAD' named entity 'TEACHING HOSPITAL' named entity 'CONCENTRATIONS' named entity 'MICS' named entity 'DISEASE' named entity 'THIRTY-FIVE' named entity 'CLINDAMYCIN' named entity 'CULTURE' named entity 'ISOLATES' named entity 'ETEST' named entity 'POPULATION' named entity 'STUDY' named entity 'MALE GENDER' named entity '100' named entity 'INTERMEDIATE RESISTANCE' named entity 'PATIENT' named entity 'CASES' named entity 'PATIENTS' named entity 'CARRIED' named entity 'LARGE' named entity 'DISCHARGES' named entity 'CLOSTRIDIUM DIFFICILE' named entity 'STRAINS' named entity 'HAEMATOLOGY' named entity 'AGED' named entity 'MG%' named entity 'RESULTS' named entity 'DETECTION' named entity 'GENES' named entity 'SUSCEPTIBLE' named entity 'LOW' named entity 'TOXIGENIC CLOSTRIDIUM DIFFICILE' named entity 'MINIMUM'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software