About: CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection
Creator	Rottier, Peter Karnam, Guruswamy Meyaard, Linde Coenjaerts, Frank De Haan, Cornelis Grinwis, Guy Rygiel, Tomasz Ressing, Maaike
Source	Medline; PMC
abstract	Immunological checkpoints, such as the inhibitory CD200 receptor (CD200R), play a dual role in balancing the immune system during microbial infection. On the one hand these inhibitory signals prevent excessive immune mediated pathology but on the other hand they may impair clearance of the pathogen. We studied the influence of the inhibitory CD200-CD200R axis on clearance and pathology in two different virus infection models. We find that lack of CD200R signaling strongly enhances type I interferon (IFN) production and viral clearance and improves the outcome of mouse hepatitis corona virus (MHV) infection, particularly in female mice. MHV clearance is known to be dependent on Toll like receptor 7 (TLR7)-mediated type I IFN production and sex differences in TLR7 responses previously have been reported for humans. We therefore hypothesize that CD200R ligation suppresses TLR7 responses and that release of this inhibition enlarges sex differences in TLR7 signaling. This hypothesis is supported by our findings that in vivo administration of synthetic TLR7 ligand leads to enhanced type I IFN production, particularly in female Cd200(−/−) mice and that CD200R ligation inhibits TLR7 signaling in vitro. In influenza A virus infection we show that viral clearance is determined by sex but not by CD200R signaling. However, absence of CD200R in influenza A virus infection results in enhanced lung neutrophil influx and pathology in females. Thus, CD200-CD200R and sex are host factors that together determine the outcome of viral infection. Our data predict a sex bias in both beneficial and pathological immune responses to virus infection upon therapeutic targeting of CD200-CD200R.
has issue date	2012-05-17(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1002710
bibo:pmid	22615569
has license	cc-by
sha1sum (hex)	48346dec8180ad8bc1f1bcab9fb95f52d13c920f
schema:url	https://doi.org/10.1371/journal.ppat.1002710
resource representing a document's title	CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection
has PubMed Central identifier	PMC3355091
has PubMed identifier	22615569
schema:publication	PLoS Pathog
resource representing a document's body	covid:48346dec8180ad8bc1f1bcab9fb95f52d13c920f#body_text
is schema:about of	named entity 'vivo' named entity 'mediated' named entity 'bias' named entity 'Receptor' named entity 'Responses' named entity 'SIGNALS' named entity 'PREVENT' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'RECEPTOR' named entity 'ROLE' named entity 'IMMUNOLOGICAL' named entity 'EXCESSIVE' named entity 'FINDINGS' named entity 'CD200' named entity 'LIGAND' named entity 'INTERFERON ' named entity 'RESPONSES' named entity 'REPORTED' named entity 'THERAPEUTIC' named entity 'MODELS' named entity 'CLEARANCE' named entity 'FEMALE' named entity 'SYNTHETIC' named entity 'IN VIVO' named entity 'HAVE' named entity 'LUNG' named entity 'SEX-SPECIFIC' named entity 'TLR7' named entity 'CD200' named entity 'VIRAL INFECTION' named entity 'RECEPTOR' named entity 'ADMINISTRATION' named entity 'SEX DIFFERENCES' named entity 'CORONA' named entity 'IMMUNE SYSTEM' named entity 'IN VITRO' named entity 'PATHOGEN' named entity 'IMMUNE RESPONSES' named entity 'THESE' named entity 'INFECTION' named entity 'MICE' named entity 'TARGETING' named entity 'MEDIATED' named entity 'TYPE I IFN PRODUCTION' named entity 'AXIS' named entity 'HYPOTHESIS' named entity 'DIFFERENT' named entity 'IMMUNE MEDIATED' named entity 'TOLL LIKE RECEPTOR 7' named entity 'SEX BIAS' named entity 'RESULTS' named entity 'VIRUS INFECTION' named entity 'OUR' named entity 'MHV' named entity 'ABSENCE OF' named entity 'BUT' named entity 'HAND' named entity 'VIRAL INFECTION' named entity 'TLR7' named entity 'TYPE I INTERFERON' named entity 'MICROBIAL INFECTION' named entity 'INFLUENCE' named entity 'VIRUS' named entity 'SUPPRESSES' named entity 'NEUTROPHIL' named entity 'KNOWN' named entity 'PREDICT' named entity 'DETERMINE' named entity 'IMPROVES' named entity 'CD200R' named entity 'ENHANCED' named entity 'VIRAL CLEARANCE' named entity 'BENEFICIAL' named entity 'OUTCOME'

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