About: Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling
Creator	Yu, Jie Xu, Zhiwen Che, Lianqiang Chen, Daiwen He, Jun Huang, Zhiqing Luo, Junqiu Luo, Yuheng Mao, Xiangbing Wang, Lan Wu, Aimin Wu, De Yu, Bing Zhang, Keying Zhao, Jun Zheng, Ping
source	Medline; PMC
abstract	Infection with transmissible gastroenteritis virus (TGEV) has been associated with villous atrophy within 48 h, which seriously disrupts intestinal homeostasis. However, the underlying mechanisms remain elusive. In this study, we found that TGEV infection severely disrupted intestinal homeostasis via inhibition of self-renewal and differentiation in Lgr5 intestinal stem cells (ISCs). Profoundly, TGEV-encoded NSP10/NSP16 protein complex-mediated the inactivation of Notch signaling provided a mechanistic explanation for this phenomenon. Initial invasions by TGEV-targeted Paneth cells through aminopeptidase N (APN) receptor, then inducing mitochondrial damage and ROS generation in them, ultimately causing Paneth cell decrease and loss of Notch factors (DII4 and Hes5), which are essential for Lgr5 ISCs self-renewal and differentiation. Interestingly, loss of Notch signaling induced goblet cells differentiation at the cost of absorptive enterocytes and promoted mucins secretion, which accelerated TGEV replication. Therefore, the more differentiation of goblet cells, the greater TGEV infection in jejunum. These results provide a detailed mechanistic pathway by which villous atrophy sharply occurs in TGEV-infected jejunum within 48 h. Thus, the pathogenesis of TGEV can be described as a “bottom up scenario”, which is contrary to the traditional “top down” hypothesis. Together, our findings provide a potential link between diarrheal virus infection and crypt cells response that regulates Paneth cells function and Lgr5 ISCs fate and could be exploited for therapeutic application.
has issue date	2020-01-20(xsd:dateTime)
bibo:doi	10.1038/s41419-020-2233-6
bibo:pmid	31959773
has license	cc-by
sha1sum (hex)	486ad1536fb8f8a3ac0f4a38ee97fc8af2435cc0
schema:url	https://doi.org/10.1038/s41419-020-2233-6
resource representing a document's title	Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling
has PubMed Central identifier	PMC6971083
has PubMed identifier	31959773
schema:publication	Cell Death Dis
resource representing a document's body	covid:486ad1536fb8f8a3ac0f4a38ee97fc8af2435cc0#body_text
is schema:about of	named entity 'STEM CELLS' named entity 'TARGETS' named entity 'exploited' named entity 'Initial' named entity 'villous atrophy' named entity 'infection' named entity 'NSP10' named entity 'PANETH CELLS' covid:arg/486ad1536fb8f8a3ac0f4a38ee97fc8af2435cc0 named entity 'NOTCH SIGNALING' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'CRYPT' named entity 'HES5' named entity 'PHENOMENON' named entity 'OUR' named entity 'VIRUS INFECTION' named entity 'INITIAL' named entity 'REPLICATION' named entity 'FOUND' named entity 'INFECTION' named entity 'DIFFERENTIATION' named entity 'APPLICATION' named entity 'LOSS OF' named entity 'VILLOUS ATROPHY' named entity 'RESULTS' named entity 'HOMEOSTASIS' named entity 'MUCINS' named entity 'INDUCED' named entity 'HYPOTHESIS' named entity 'MITOCHONDRIAL DAMAGE' named entity 'TARGETED' named entity 'ESSENTIAL' named entity 'CELLS FUNCTION' named entity 'LGR5' named entity 'TO INHIBIT' named entity 'PANETH CELL' named entity 'UNDERLYING' named entity 'DESCRIBED' named entity 'PANETH CELLS' named entity 'NOTCH' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'INTESTINAL' named entity 'PROTEIN COMPLEX' named entity 'INTESTINAL' named entity 'ENTEROCYTES' named entity 'INHIBITION' named entity 'PATHWAY' named entity 'ABSORPTIVE' named entity 'CAUSING' named entity 'ENCODED' named entity 'ISCS' named entity 'GOBLET CELLS' named entity 'ROS GENERATION' named entity 'SCENARIO' named entity 'INFECTED' named entity 'AMINOPEPTIDASE N' named entity 'ACCELERATED' named entity 'STUDY' named entity 'DETAILED' named entity 'PROVIDE' named entity 'INDUCING' named entity 'CELLS DIFFERENTIATION' named entity 'RECEPTOR' named entity 'THERAPEUTIC' named entity 'MECHANISMS' named entity 'PROVIDED'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software