About: DNA Repair Protein OGG1 in Pulmonary Infection and Other Inflammatory Lung Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	DNA Repair Protein OGG1 in Pulmonary Infection and Other Inflammatory Lung Diseases
Creator	Wu, Min Lin, Ping Li, Guoping Li, G Wu, · Jiang, Jianxin Jiang, J Lin, P Pu, Q Pu, Qinqin Qin, Shugang Qin, · Schettler, Jacob Schettler, · Thoemke, Mariah Thoemke, ·
Source	PMC
abstract	In the last decades, extensive research has uncovered functional roles and underlying mechanisms of DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) in the pathogenesis of inflammatory response in infection and other diseases in the lung. OGG1 excises 8-oxo-7,8-dihydroguanine (8-oxo-dG) lesion on DNA that is often induced by generation of reactive oxygen species (ROS) and has been linked to mutations, cancer development, and tissue damage. Most, if not all, environmental toxic agents and mammalian cellular metabolites elicit the generation of ROS, either directly, indirectly, or both, which is among the first cellular responses. ROS in combination with other oxidative molecules/moieties are recognized as a major factor for killing invading pathogens but meanwhile can cause tissue damage. ROS potentially modify proteins, lipids, and DNA due to the strong molecular reactivity. While oxidative stress causes increased levels of all types of oxidatively modified DNA bases, accumulation of 8-oxo-dG in the DNA has been singled out to be a main culprit linking to various inflammatory disease processes. Oxidatively damaged DNA bases such as 8-oxo-dG are primarily repaired by the base excision repair (BER) mechanism, in which OGG1, as the lesion recognition enzyme, plays a fundamental role in fixing this DNA damage. In this chapter, we summarize the roles and potential mechanistic analyses of OGG1 in lung infection and other inflammatory diseases.
has issue date	2019-05-02(xsd:dateTime)
bibo:doi	10.1007/978-981-13-8413-4_4
has license	no-cc
sha1sum (hex)	48906d4feb8016d893ef34ea2237cede4df1c845
schema:url	https://doi.org/10.1007/978-981-13-8413-4_4
resource representing a document's title	DNA Repair Protein OGG1 in Pulmonary Infection and Other Inflammatory Lung Diseases
has PubMed Central identifier	PMC7121726
schema:publication	Oxidative Stress in Lung Diseases
resource representing a document's body	covid:48906d4feb8016d893ef34ea2237cede4df1c845#body_text
is schema:about of	named entity 'infection' named entity 'mutations' named entity 'DNA' named entity 'environmental' named entity 'molecules' named entity 'cancer' named entity 'OGG1' named entity 'PATHOGENESIS' named entity '288' named entity 'UNDERLYING' named entity 'lesion' named entity 'responses' named entity '8-oxoguanine' named entity 'uncovered' named entity 'modify' named entity 'damage' named entity 'induced' named entity 'reactive oxygen species (ROS)' named entity 'pathogenesis' named entity 'inflammatory response' named entity 'excises' named entity 'OGG1' named entity 'reactive oxygen species' named entity '8-oxo-dG' named entity 'pathogenesis' named entity 'DNA glycosylase' named entity '8-oxoguanine' named entity 'lung' named entity 'tissue damage' named entity 'Lung Diseases' named entity 'OGG1' named entity 'DNA Repair' named entity 'ROS' named entity 'pathogens' named entity 'DNA damage' named entity 'public health issue' named entity 'sugar' named entity 'inflammation' named entity 'pathogens' named entity 'oxidation' named entity 'OGG1' named entity 'OGG1' named entity 'OGG1' named entity 'lung infection' named entity 'Protein' named entity 'ROS' named entity 'TNF-α' named entity 'inflammation' named entity 'NLRP3' named entity 'mitochondrial' named entity 'surface antigens' named entity 'infection' named entity 'inflammatory processes' named entity 'OGG1' named entity 'inflammatory responses' named entity 'hematopoietic cell' named entity 'bacteria' named entity 'host cells' named entity 'phosphate' named entity 'external environment' named entity 'apoptosis' named entity 'infection' named entity 'immune response' named entity 'pyrin domain' named entity 'mtDNA' named entity 'stress factors' named entity 'ROS' named entity 'Panduri'

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