About: Multiplex Respiratory Virus Testing for Antimicrobial Stewardship: A Prospective Assessment of Antimicrobial Use and Clinical Outcomes Among Hospitalized Adults

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Multiplex Respiratory Virus Testing for Antimicrobial Stewardship: A Prospective Assessment of Antimicrobial Use and Clinical Outcomes Among Hospitalized Adults
Creator	Dendukuri, Nandini Frenette, Charles Semret, Makeda Papenburg, Jesse Schiller, Ian Mcneil, Shelly Jardin, Barbara Loo, Vivian
source	Medline; PMC
abstract	BACKGROUND: Respiratory tract infections are frequent causes of hospitalization and initiation of empirical antimicrobial therapy. Testing for a broad panel of respiratory viruses has been advocated as a useful tool for antibiotic stewardship. We conducted a prospective observational study to assess the impact of rapid viral test results on antimicrobial prescriptions and clinical outcomes among hospitalized adults. METHODS: Eight hundred patients admitted with respiratory symptoms were tested by a 12-virus respiratory panel (RVP) during 3 consecutive winters in Montreal, Canada. The primary outcome measure was change in antimicrobial prescriptions (ie, de-escalation of empirical antimicrobial therapy or commencement of new antimicrobial therapy) after RVP results were available. Clinical outcomes were also assessed. RESULTS: Influenza virus was identified in 53% of individuals in the study population, and other viruses were identified in 10%. Influenza virus positivity was associated with shorter duration of hospitalization and appropriate antiviral management. Antibiotic management was most significantly correlated with radiographic suspicion of pneumonia and less so with results of the RVP. Positivity for viruses other than influenza virus was not correlated with significantly different outcomes. CONCLUSIONS: Physicians respond to results of testing for influenza virus when managing hospitalized adult patients but respond less to test results for other viruses. These data can inform the design of stewardship interventions and the selection of viral testing panels for hospitalized patients.
has issue date	2017-06-19(xsd:dateTime)
bibo:doi	10.1093/infdis/jix288
bibo:pmid	29149338
has license	bronze-oa
sha1sum (hex)	48df5d97aaca671d3c92656500cd75ce9e06d817
schema:url	https://doi.org/10.1093/infdis/jix288
resource representing a document's title	Multiplex Respiratory Virus Testing for Antimicrobial Stewardship: A Prospective Assessment of Antimicrobial Use and Clinical Outcomes Among Hospitalized Adults
has PubMed Central identifier	PMC5853820
has PubMed identifier	29149338
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:48df5d97aaca671d3c92656500cd75ce9e06d817#body_text
is schema:about of	named entity 'PROSPECTIVE' named entity 'MULTIPLEX' named entity 'ANTIMICROBIAL STEWARDSHIP' named entity 'ANTIMICROBIAL' named entity 'ADULTS' named entity 'RESPIRATORY VIRUS' named entity 'CLINICAL OUTCOMES' named entity 'ASSESSMENT' named entity 'VIRUS TESTING' named entity '923' named entity 'PAGES' named entity 'USE' named entity 'HOSPITALIZED' named entity 'COMMENTARY' named entity 'EDITORIAL' covid:arg/48df5d97aaca671d3c92656500cd75ce9e06d817 named entity 'longitudinal studies' named entity 'viruses' named entity 'antibiotics' named entity 'influenza virus' named entity 'pneumonia' named entity 'data collected' named entity 'patient outcomes' named entity 'influenza' named entity 'real-time polymerase chain reaction' named entity 'Antimicrobial' named entity 'antibiotics' named entity 'antibiotics' named entity 'influenza' named entity 'turnaround time' named entity 'antibiotics' named entity 'virus' named entity 'positive test' named entity 'respiratory tract infections' named entity 'pneumonia' named entity 'influenza virus' named entity 'tertiary care' named entity 'moxifloxacin' named entity 'antimicrobial' named entity 'thromboembolism' named entity 'clinical outcomes' named entity 'antimicrobial' named entity 'influenza-like' named entity 'influenza virus' named entity 'Clostridium difficile infection' named entity 'Antibiotic' named entity 'oseltamivir' named entity 'antivirals' named entity 'antimicrobial' named entity 'infection' named entity 'viruses' named entity 'antibiotics' named entity 'cough' named entity 'Canada' named entity 'respiratory tract infections' named entity 'antivirals' named entity 'procalcitonin' named entity 'radiographic' named entity 'antibiotics' named entity 'antivirals' named entity 'ICU' named entity 'influenza virus' named entity 'respiratory tract infection' named entity 'antivirals' named entity '95% CI' named entity 'influenza virus' named entity 'Charlson index' named entity 'influenza' named entity 'clinical characteristics' named entity 'clinical outcomes' named entity 'influenza B virus' named entity 'Cox proportional hazards models' named entity 'viral pathogens' named entity 'antivirals'

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