About: Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients
Creator	Baldanti, Fausto Campanini, Giulia Piralla, Antonio Rovida, Francesca Genini, Emilia Gerna, Giuseppe Marchi, Antonietta Percivalle, Elena Sarasini, Antonella
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Human respiratory coronavirus (hCoV) HKU1 infections were reported for the first time in 2005 in Hong Kong. OBJECTIVE: To investigate epidemiological, clinical, and diagnostic features of HKU1 infections. STUDY DESIGN: Longitudinal, prospective study from November 2005 through May 2006 in a hospitalised patient population. RESULTS: Overall, 48/426 (11.3%) patients were found to be infected by hCoV acute respiratory tract infections (ARTI). Of these, 10 (19.2%) were caused by HKU1 (6 single infections and 4 coinfections) during the period January–May 2006. Diagnosis was made by using RT-PCR for all four hCoVs, and in parallel, in-house developed group-specific monoclonal antibodies (MAbs) for HKU1 and 229E. HKU1-specific MAb was able to retrospectively identify 8 of 10 HKU1 strains detected by RT-PCR. Phylogenetic analysis showed that four HKU1 strains were genotype A and six genotype B. In HKU1-infected patients, the predominant clinical symptom was rhinorrhea (nine patients). Within group II hCoV, HKU1-infected patients had a significantly lower rate of lower ARTI compared to OC43-infected patients. CONCLUSION: HKU1 hCoV strains circulated in northern Italy during the winter–spring season 2005–2006. Both HKU1 genotypes were detected. HKU1-specific MAb may contribute to the rapid diagnosis of HKU1 infections currently performed by RT-PCR.
has issue date	2007-01-10(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2006.12.008
bibo:pmid	17222582
has license	no-cc
sha1sum (hex)	48f372569e276faae0513c70415a25b36be282fd
schema:url	https://doi.org/10.1016/j.jcv.2006.12.008
resource representing a document's title	Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients
has PubMed Central identifier	PMC7108341
has PubMed identifier	17222582
schema:publication	J Clin Virol
resource representing a document's body	covid:48f372569e276faae0513c70415a25b36be282fd#body_text
is schema:about of	named entity 'infections' named entity 'time' named entity 'HUMAN' named entity 'NOVEMBER' named entity 'OBJECTIVE' named entity 'DIAGNOSTIC' named entity 'TIME' named entity 'BACKGROUND' named entity 'PATIENTS' named entity 'RESPIRATORY' named entity 'CORONAVIRUS INFECTIONS' named entity 'HONG KONG' named entity 'ITALIAN' named entity 'REPORTED' named entity 'CLINICAL' named entity 'INFECTIONS' named entity 'FEATURES' named entity 'CORONAVIRUS HKU1' named entity 'PROSPECTIVE STUDY' named entity 'TO INVESTIGATE' named entity 'CORONAVIRUS' named entity 'HUMAN' named entity 'RESPIRATORY' named entity 'EPIDEMIOLOGICAL' named entity 'STUDY DESIGN' named entity 'PATIENT POPULATION' named entity 'LONGITUDINAL' covid:arg/48f372569e276faae0513c70415a25b36be282fd named entity 'Human' named entity 'coronavirus' named entity '2006' named entity 'infections' named entity 'epidemiological' named entity 'HKU1' named entity 'immunocompromised' named entity 'OC43' named entity 'inoculated' named entity 'MAbs' named entity 'molecular techniques' named entity 'RT-PCR' named entity 'syncytial' named entity 'RT-PCR' named entity 'DFA' named entity 'Hong-Kong' named entity 'virus' named entity 'pneumonia' named entity 'NL63' named entity 'respiratory tract infection' named entity 'sequenced' named entity 'viruses' named entity 'excretion' named entity 'OC43' named entity 'MAb' named entity '2005a' named entity 'Italy' named entity 'rhinorrhea' named entity 'kidney' named entity 'HKU1' named entity 'bronchiolitis' named entity 'HKU1' named entity 'viruses' named entity 'Hong Kong' named entity 'hematopoietic stem cell transplantation' named entity 'genotypes' named entity '229E' named entity 'HKU1' named entity 'HKU1' named entity 'HuH7' named entity 'rhinovirus' named entity 'HKU1' named entity 'RT-PCR' named entity 'OC43' named entity 'direct fluorescent antibody'

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