About: Three-Dimensional Normal Human Neural Progenitor Tissue-Like Assemblies: A Model of Persistent Varicella-Zoster Virus Infection

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About: Three-Dimensional Normal Human Neural Progenitor Tissue-Like Assemblies: A Model of Persistent Varicella-Zoster Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Three-Dimensional Normal Human Neural Progenitor Tissue-Like Assemblies: A Model of Persistent Varicella-Zoster Virus Infection
Creator	Osterrieder, Nikolaus Cohrs, Randall Everett, Roger Goodwin, Thomas Kaufer, Benedikt Mccarthy, Maureen
Source	Medline; PMC
abstract	Varicella-zoster virus (VZV) is a neurotropic human alphaherpesvirus that causes varicella upon primary infection, establishes latency in multiple ganglionic neurons, and can reactivate to cause zoster. Live attenuated VZV vaccines are available; however, they can also establish latent infections and reactivate. Studies of VZV latency have been limited to the analyses of human ganglia removed at autopsy, as the virus is strictly a human pathogen. Recently, terminally differentiated human neurons have received much attention as a means to study the interaction between VZV and human neurons; however, the short life-span of these cells in culture has limited their application. Herein, we describe the construction of a model of normal human neural progenitor cells (NHNP) in tissue-like assemblies (TLAs), which can be successfully maintained for at least 180 days in three-dimensional (3D) culture, and exhibit an expression profile similar to that of human trigeminal ganglia. Infection of NHNP TLAs with cell-free VZV resulted in a persistent infection that was maintained for three months, during which the virus genome remained stable. Immediate-early, early and late VZV genes were transcribed, and low-levels of infectious VZV were recurrently detected in the culture supernatant. Our data suggest that NHNP TLAs are an effective system to investigate long-term interactions of VZV with complex assemblies of human neuronal cells.
has issue date	2013-08-01(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003512
bibo:pmid	23935496
has license	cc0
sha1sum (hex)	492ae848b7e2b20047ac406af1c7712ea6255461
schema:url	https://doi.org/10.1371/journal.ppat.1003512
resource representing a document's title	Three-Dimensional Normal Human Neural Progenitor Tissue-Like Assemblies: A Model of Persistent Varicella-Zoster Virus Infection
has PubMed Central identifier	PMC3731237
has PubMed identifier	23935496
schema:publication	PLoS Pathog
resource representing a document's body	covid:492ae848b7e2b20047ac406af1c7712ea6255461#body_text
is schema:about of	named entity 'LIKE' named entity 'PERSISTENT' named entity 'three-dimensional' named entity 'system' named entity 'remained' named entity 'culture' named entity 'Varicella-zoster virus' named entity 'construction' named entity 'VZV' named entity 'Varicella' named entity 'Normal' named entity 'TISSUE' named entity 'VIRUS INFECTION' named entity 'STUDIES' named entity 'LATENT' named entity 'SYSTEM' named entity 'PROGENITOR CELLS' named entity 'APPLICATION' named entity 'GANGLIA' named entity 'GENOME' named entity 'REACTIVATE' named entity 'NEUROTROPIC' named entity 'NEURAL PROGENITOR' named entity 'INFECTIONS' named entity 'LOW' named entity 'CAUSES' named entity 'CELL' named entity 'EFFECTIVE' named entity 'CAUSE' named entity 'ATTENUATED' named entity 'CELLS' named entity 'GANGLIONIC' named entity 'LEVELS' named entity 'AND LATE' named entity 'CONSTRUCTION' named entity 'PERSISTENT INFECTION' named entity 'SUGGEST' named entity 'NEURONS' named entity 'PATHOGEN' named entity 'DATA' named entity 'TRANSCRIBED' named entity 'THREE MONTHS' named entity 'THEIR' named entity 'INTERACTIONS' named entity 'FREE' named entity 'MAINTAINED' named entity 'THREE-DIMENSIONAL' named entity 'INFECTION' named entity 'LIVE' named entity 'GENES' named entity 'VIRUS' named entity 'INTERACTION' named entity 'VARICELLA-ZOSTER VIRUS INFECTION' named entity 'VARICELLA' named entity 'ESTABLISH' named entity 'DETECTED' named entity 'ZOSTER' named entity 'CULTURE SUPERNATANT' named entity 'THREE-DIMENSIONAL' named entity 'COMPLEX' named entity 'STUDY' named entity 'REMOVED' named entity 'ATTENTION' named entity 'EXPRESSION PROFILE' named entity 'IMMEDIATE' named entity 'DESCRIBE' named entity 'LIMITED' named entity 'MODEL OF' named entity 'INFECTIOUS' named entity 'MUCH' named entity 'RECEIVED' named entity 'SPAN' named entity 'CULTURE' named entity 'NORMAL' named entity 'NORMAL' named entity 'ZOSTER'

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