About: A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken

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About: A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken
Creator	Li, Ning Wang, Jie Shu, Dingming Hu, Xiaoxiang Luo, Chenglong Ma, Jie Qu, Hao
Source	Elsevier; Medline; PMC
abstract	Coronaviruses are a hot research topic because they can cause severe diseases in humans and animals. Infectious bronchitis virus (IBV), belonging to gamma-coronaviruses, causes a highly infectious respiratory viral disease and can result in catastrophic economic losses to the poultry industry worldwide. Unfortunately, the genetic basis of the host immune responses against IBV is poorly understood. In the present study, the antibody levels against IBV post-immunization were measured by an enzyme-linked immunosorbent assay in the serum of 511 individuals from a commercial chicken (Gallus gallus) population. A genome-wide association study using 43,211 single nucleotide polymorphism markers was performed to identify the major loci affecting the immune response against IBV. This study detected 20 significant (P < 1.16 × 10(−6)) effect single nucleotide polymorphisms for the antibody level against IBV. These single nucleotide polymorphisms were distributed on five chicken chromosomes (GGA), involving GGA1, GGA3, GGA5, GGA8, and GGA9. The genes in the 1-Mb windows surrounding each single nucleotide polymorphism with significant effect for the antibody level against IBV were associated with many biological processes or pathways related to immunity, such as the defense response and mTOR signaling pathway. A genomic region containing a cluster of 13 beta-defensin (GAL1–13) and interleukin-17F genes on GGA3 probably plays an important role in the immune response against IBV. In addition, the major loci significantly associated with the antibody level against IBV on GGA1 and GGA5 could explain about 12% and 13% of the phenotypic variation, respectively. This study suggested that the chicken genome has several important loci affecting the immune response against IBV, and increases our knowledge of how to control outbreaks of infectious bronchitis.
has issue date	2013-12-11(xsd:dateTime)
bibo:doi	10.1016/j.meegid.2013.12.004
bibo:pmid	24333371
has license	no-cc
sha1sum (hex)	4939a8ffb831e245e793678ca58921a9cea68872
schema:url	https://doi.org/10.1016/j.meegid.2013.12.004
resource representing a document's title	A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken
has PubMed Central identifier	PMC7106259
has PubMed identifier	24333371
schema:publication	Infect Genet Evol
resource representing a document's body	covid:4939a8ffb831e245e793678ca58921a9cea68872#body_text
is schema:about of	named entity 'MAJOR' named entity 'AFFECTING' named entity 'single nucleotide polymorphism' named entity 'defense response' named entity 'phenotypic variation' named entity 'Infectious bronchitis virus' named entity 'detected' named entity 'antibody' named entity 'ASSOCIATED WITH' named entity 'DISEASES' named entity 'CAUSE' named entity 'DETECTED' named entity 'RESPIRATORY' named entity 'IMMUNE RESPONSES' named entity 'WORLDWIDE' named entity 'OUR' named entity 'INCREASES' named entity 'DISTRIBUTED' named entity 'HOW' named entity 'CHICKEN' named entity 'POPULATION' named entity 'RELATED' named entity 'PHENOTYPIC VARIATION' named entity 'STUDY' named entity 'GALLUS' named entity 'CLUSTER' named entity 'PATHWAYS' named entity 'BIOLOGICAL PROCESSES' named entity 'CORONAVIRUSES' named entity '28P' named entity '806' named entity 'GENES' named entity 'TO IDENTIFY' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'CHROMOSOMES' named entity 'KNOWLEDGE' named entity 'GGA3' named entity 'INDIVIDUALS' named entity 'PRESENT' named entity 'GENETIC' named entity 'ANIMALS' named entity 'IMMUNE RESPONSE' named entity 'GENOME' named entity 'INFECTIOUS BRONCHITIS' named entity 'BELONGING' named entity 'REGION' named entity 'PROBABLY' named entity 'SERUM' named entity 'GENOME-WIDE ASSOCIATION STUDY' named entity 'PERFORMED' named entity 'ECONOMIC' named entity 'DEFENSIN' named entity 'HIGHLY' named entity 'ROLE' named entity 'POULTRY INDUSTRY' named entity 'POORLY' named entity 'OUTBREAKS' named entity 'CONTAINING' named entity 'MTOR SIGNALING PATHWAY' named entity 'LEVELS' named entity 'HOST' named entity 'CHICKEN' named entity 'CAUSES' named entity 'SINGLE NUCLEOTIDE POLYMORPHISM' named entity 'ADDITION' named entity 'IMMUNE RESPONSE' named entity 'GENOME-WIDE ASSOCIATION STUDY' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'LOCI' named entity 'WINDOWS' named entity 'MARKERS' named entity 'BASIS' named entity 'TO CONTROL' named entity 'INTERLEUKIN-17F' named entity 'TOPIC'

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