About: Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens
Creator	Barichievy, Samantha Buck, Amy Fraser, Iain Jona, Ghil Karpilow, Jon Leake, Devin Mhlanga, Musa Smith, Queta Stambas, John Andersen, Lauren Lowenthal, John Stewart, Cameron Meliopoulos, Victoria Bean, Andrew Smith, S Tompkins, S Tripp, Ralph Van Beusechem, Victor Andersen, V Barichievy, M Bean, J Beusechem, Van Birrer, Katherine Buck, J Fraser, V Host, R Leake, Q Mhlanga, I Simpson, K Simpson, Kaylene Stewart, J Tompkins, C Tripp, G
source	Medline; PMC
abstract	Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and mammalian species by exploiting host cell functions. Genome-wide RNA interference (RNAi) has proven to be a powerful tool for identifying the host molecules that participate in each step of virus replication. Meta-analysis of findings from genome-wide RNAi screens has shown influenza virus to be dependent on functional nodes in host cell pathways, requiring a wide variety of molecules and cellular proteins for replication. Because rapid evolution of the influenza A viruses persistently complicates the effectiveness of vaccines and therapeutics, a further understanding of the complex host cell pathways coopted by influenza virus for replication may provide new targets and strategies for antiviral therapy. RNAi genome screening technologies together with bioinformatics can provide the ability to rapidly identify specific host factors involved in resistance and susceptibility to influenza virus, allowing for novel disease intervention strategies.—Meliopoulos, V. A., Andersen, L. E., Birrer, K. F., Simpson, K. J., Lowenthal, J. W., Bean, A. G. D., Stambas, J., Stewart, C. R., Tompkins, S. M., van Beusechem, V. W., Fraser, I., Mhlanga, M., Barichievy, S., Smith, Q., Leake, D., Karpilow, J., Buck, A., Jona, G., Tripp, R. A. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.
has issue date	2012-01-12(xsd:dateTime)
bibo:doi	10.1096/fj.11-193466
bibo:pmid	22247330
has license	green-oa
sha1sum (hex)	4983d3e65ccf0632288ee42f5a5bb3cc9edb3a63
schema:url	https://doi.org/10.1096/fj.11-193466
resource representing a document's title	Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens
has PubMed Central identifier	PMC3316894
has PubMed identifier	22247330
schema:publication	The FASEB Journal
resource representing a document's body	covid:4983d3e65ccf0632288ee42f5a5bb3cc9edb3a63#body_text
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