About: Role of sialic acids in rotavirus infection

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About: Role of sialic acids in rotavirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of sialic acids in rotavirus infection
Creator	López, Susana Isa, Pavel Arias, F Carlos, ·
topic	covid:49a64df41fdf813dbd54dc77983d9b87ee8122de#this
Source	Medline; PMC
abstract	Rotaviruses are the leading cause of childhood diarrhea. The entry of rotaviruses into the host cell is a complex process that includes several interactions of the outer layer proteins of the virus with different cell surface molecules. The fact that neuraminidase treatment of the cells, or preincubation of the virus with sialic acid-containing compounds decrease the infectivity of some rotavirus strains, suggested that these viruses interact with sialic acid on the cell surface. The infectivity of some other rotavirus strains is not affected by neuraminidase treatment of the cells, and therefore they are considered neuraminidase-resistant. However, the current evidence suggests that even these neuraminidase-resistant strains might interact with sialic acids located in context different from that of the sialic acids used by the neuraminidase-sensitive strains. This review summarizes our current knowledge of the rotavirus-sialic acid interaction, its structural basis, the specificity with which distinct rotavirus isolates interact with sialic acid-containing compounds, and also the potential use of these compounds as therapeutic agents.
has issue date	2006-01-01(xsd:dateTime)
bibo:doi	10.1007/s10719-006-5435-y
bibo:pmid	16575520
has license	no-cc
sha1sum (hex)	49a64df41fdf813dbd54dc77983d9b87ee8122de
schema:url	https://doi.org/10.1007/s10719-006-5435-y
resource representing a document's title	Role of sialic acids in rotavirus infection
has PubMed Central identifier	PMC7087688
has PubMed identifier	16575520
schema:publication	Glycoconj J
resource representing a document's body	covid:49a64df41fdf813dbd54dc77983d9b87ee8122de#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/49a64df41fdf813dbd54dc77983d9b87ee8122de
is schema:about of	named entity 'cell' named entity 'cell' named entity 'HOST CELL' named entity 'OUR' named entity 'THERAPEUTIC AGENTS' named entity 'complex' named entity 'agents' named entity 'basis' named entity 'interactions' named entity 'molecules' named entity 'hemagglutination' named entity 'infectivity' named entity 'coronaviruses' named entity 'substrates' named entity 'infectivity' named entity 'kidney' named entity 'DS-1' named entity 'protein' named entity 'erythrocytes' named entity 'cell' named entity 'therapeutic' named entity 'interact' named entity 'strains' named entity 'rotavirus' named entity 'viruses' named entity 'virus' named entity 'sialic acids' named entity 'interact' named entity 'cell surface' named entity 'neuraminidase' named entity 'interact' named entity 'virus' named entity 'neuraminidase' named entity 'sialic acids' named entity 'infection' named entity 'receptor' named entity 'antibodies' named entity 'phosphate' named entity 'VP4 protein' named entity 'glycolipid' named entity 'infectivity' named entity 'GM1' named entity 'tyrosine' named entity 'rotavirus' named entity 'digestion' named entity 'VP8' named entity 'sialic acid' named entity 'cell line' named entity 'gastroenteritis' named entity 'Sia' named entity 'arginine' named entity 'VP7' named entity 'gangliosides' named entity 'cell surface' named entity 'rotavirus' named entity 'rotavirus' named entity 'rotavirus' named entity 'GM1' named entity 'rotavirus' named entity 'rotavirus' named entity 'rotavirus' named entity 'TLPs' named entity 'gangliosides' named entity 'Sendai virus' named entity 'RNA polymerase' named entity 'VP8' named entity 'rotavirus' named entity 'VP8' named entity 'glycolipids' named entity 'Sia' named entity 'mucins' named entity 'neuraminic acid' named entity 'etiological agent' named entity 'cell surface' named entity 'inhibitory activity' named entity 'sialidases'

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