About: Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara
Creator	Jordan, Ingo Sandig, Volker Leendertz, Fabian Horn, Deborah Oehmke, Stefanie
Source	Elsevier; Medline; PMC
abstract	Abstract Bats are reservoir hosts for a spectrum of infectious diseases. Some pathogens (such as Hendra, Nipah and Marburg viruses) appear to use mainly fruit bats as reservoir. We describe designed immortalization of primary fetal cells from the Egyptian fruit bat (Rousettus aegyptiacus) to facilitate isolation and characterization of pathogens associated with these mammals. Three cell lines with different properties were recovered and successful immortalization was confirmed by continuous cultivation for over 18 months. Surprisingly, the cell lines are fully permissive for a highly attenuated poxvirus, modified vaccinia Ankara (MVA). MVA is a safe and well characterized vaccine vector that cannot replicate in most mammalian cells. High permissivity of Rousettus cell lines could justify testing bats for susceptibility to MVA as a replication competent vector with low zoonotic potential to induce herd immunity in bat colonies against viruses causing rabies or haemorrhagic fevers.
has issue date	2009-10-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2009.06.007
bibo:pmid	19540275
has license	els-covid
sha1sum (hex)	49bf586a2753b963b4ebdf53c3555b5fe445bffa
schema:url	https://doi.org/10.1016/j.virusres.2009.06.007
resource representing a document's title	Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara
has PubMed Central identifier	PMC7172177
has PubMed identifier	19540275
schema:publication	Virus Research
resource representing a document's body	covid:49bf586a2753b963b4ebdf53c3555b5fe445bffa#body_text
is schema:about of	named entity 'fetal' named entity 'cell lines' named entity 'cell lines' named entity 'justify' named entity 'testing' named entity 'FULLY' named entity 'VACCINE' named entity 'SUCCESSFUL' named entity 'RESERVOIR' covid:arg/49bf586a2753b963b4ebdf53c3555b5fe445bffa named entity 'continuous' named entity '18 months' named entity 'reservoir' named entity 'Rousettus' named entity 'Egyptian fruit bat' named entity 'cells' named entity 'vaccine' named entity 'vector' named entity 'Rousettus aegyptiacus' named entity 'rabies' named entity 'zoonotic potential' named entity 'viruses' named entity 'reservoir hosts' named entity 'immortalization' named entity 'vector' named entity 'herd immunity' named entity 'pathogens' named entity 'Egyptian fruit bat' named entity 'immortalization' named entity 'apoptosis' named entity 'HEK 293 cells' named entity 'Tween 20' named entity 'attenuated virus' named entity 'virus' named entity 'pathogens' named entity 'cell line' named entity 'passaging' named entity 'Arguin' named entity 'plasmid' named entity 'senescence' named entity 'recombinant vaccine' named entity 'PCR' named entity 'Infection' named entity 'Rousettus' named entity 'HEK 293' named entity 'plasmid' named entity 'virus isolation' named entity 'Hoechst 33342' named entity 'antigens' named entity 'chromosomes' named entity 'cytopathic effect' named entity 'plasmid' named entity 'fruit bat' named entity 'vector' named entity 'PBS' named entity 'bat' named entity 'BHK' named entity 'vaccine' named entity 'vector' named entity 'cowpox' named entity 'mals' named entity 'tumors' named entity 'epithelial' named entity 'Rousettus' named entity 'cell line' named entity 'Mvi' named entity 'catalyzes' named entity 'uteri' named entity 'cell lines' named entity 'endemic' named entity 'PLoS Pathogens' named entity 'coronaviruses' named entity 'Yob' named entity 'transfection' named entity 'Rousettus' named entity 'fetus' named entity 'vectors'

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