About: Interaction of L-SIGN with Hepatitis C Virus Envelope Protein E2 Up-Regulates Raf–MEK

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About: Interaction of L-SIGN with Hepatitis C Virus Envelope Protein E2 Up-Regulates Raf–MEK–ERK Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interaction of L-SIGN with Hepatitis C Virus Envelope Protein E2 Up-Regulates Raf–MEK–ERK Pathway
Creator	Wang, Wen Zhao, Lan-Juan Hao, • Qi, Tian Zhong, Ren
source	Medline; PMC
abstract	Liver/lymph node-specific intercellular adhesion molecule-3-grabbing integrin (L-SIGN) facilitates hepatitis C virus (HCV) infection through interaction with HCV envelope protein E2. Signaling events triggered by the E2 via L-SIGN are poorly understood. Here, kinase cascades of Raf–MEK–ERK pathway were defined upon the E2 treatment in NIH3T3 cells with stable expression of L-SIGN. The E2 bound to the cells through interaction with L-SIGN and such binding subsequently resulted in phosphorylation and activation of Raf, MEK, and ERK. Blockage of L-SIGN with antibody against L-SIGN reduced the E2-induced phosphorylation of Raf, MEK, and ERK. In the cells infected with cell culture-derived HCV, phosphorylation of these kinases was enhanced by the E2. Up-regulation of Raf–MEK–ERK pathway by HCV E2 via L-SIGN provides new insights into signaling cascade of L-SIGN, and might be a potential target for control and prevention of HCV infection.
has issue date	2013-01-06(xsd:dateTime)
bibo:doi	10.1007/s12013-012-9505-4
bibo:pmid	23292357
has license	no-cc
sha1sum (hex)	49e678cddeb8adeb730dfc16266f9250e609730d
schema:url	https://doi.org/10.1007/s12013-012-9505-4
resource representing a document's title	Interaction of L-SIGN with Hepatitis C Virus Envelope Protein E2 Up-Regulates Raf–MEK–ERK Pathway
has PubMed Central identifier	PMC7090805
has PubMed identifier	23292357
schema:publication	Cell Biochem Biophys
resource representing a document's body	covid:49e678cddeb8adeb730dfc16266f9250e609730d#body_text
is schema:about of	named entity 'VIRUS ENVELOPE' named entity 'Up-regulation' named entity 'facilitates' named entity 'PROTEIN ' named entity 'L-SIGN' named entity 'SPECIFIC' named entity 'UNDERSTOOD' named entity 'DERIVED' named entity 'THESE' named entity 'HCV INFECTION' named entity 'SIGNALING' named entity 'POORLY' named entity 'INSIGHTS' named entity 'INTEGRIN' named entity 'ANTIBODY' named entity 'NIH3T3' covid:arg/49e678cddeb8adeb730dfc16266f9250e609730d named entity 'DEFINED' named entity 'NODE' named entity 'BINDING' named entity 'BOUND' named entity 'SIGN' named entity 'RAF' named entity 'CELL CULTURE' named entity 'TREATMENT' named entity 'HEPATITIS C VIRUS' named entity 'ENVELOPE PROTEIN' named entity 'ERK' named entity 'SIGNALING CASCADE' named entity 'NEW' named entity 'BLOCKAGE' named entity 'PHOSPHORYLATION' named entity 'INTERACTION' named entity 'MEK-ERK PATHWAY' named entity 'CELLS' named entity 'KINASE' named entity 'REDUCED' named entity 'INFECTED' named entity 'L-SIGN' named entity 'UP-REGULATES' named entity 'RAF' named entity 'INFECTION' named entity 'TRIGGERED BY' named entity 'ACTIVATION' named entity 'ENHANCED' named entity 'CONTROL' named entity 'EVENTS' named entity 'MIGHT BE' named entity 'INTERACTION' named entity 'PROTEIN ' named entity 'ENVELOPE PROTEIN' named entity 'MEK-ERK PATHWAY' named entity 'PROVIDES' named entity 'STABLE EXPRESSION' named entity 'MEK' named entity 'HERE' named entity 'HEPATITIS C VIRUS' named entity 'KINASES' named entity 'LIVER' named entity 'TARGET' named entity 'INDUCED' named entity 'PREVENTION OF' named entity 'UP-REGULATION' named entity 'POTENTIAL' named entity 'HCV' named entity 'INTERCELLULAR ADHESION MOLECULE-3' named entity 'intercellular adhesion molecule' named entity 'protein' named entity 'MEK' named entity 'kinases' named entity 'HCV' named entity 'target' named entity 'enhanced' named entity 'Raf' named entity 'control' named entity 'Envelope' named entity 'HCV'

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