About: Transcriptome sequencing and development of an expression microarray platform for liver infection in adenovirus type 5-infected Syrian golden hamsters

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About: Transcriptome sequencing and development of an expression microarray platform for liver infection in adenovirus type 5-infected Syrian golden hamsters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptome sequencing and development of an expression microarray platform for liver infection in adenovirus type 5-infected Syrian golden hamsters
Creator	Aurora, Rajeev Toth, Karoly Spencer, Jacqueline Wold, William Ying, Baoling
Source	Elsevier; Medline; PMC
abstract	Abstract The Syrian golden hamster is an attractive animal for research on infectious diseases and other diseases. We report here the sequencing, assembly, and annotation of the Syrian hamster transcriptome. We include transcripts from ten pooled tissues from a naïve hamster and one stimulated with lipopolysaccharide. Our data set identified 42,707 non-redundant transcripts, representing 34,191 unique genes. Based on the transcriptome data, we generated a custom microarray and used this new platform to investigate the transcriptional response in the Syrian hamster liver following intravenous adenovirus type 5 (Ad5) infection. We found that Ad5 infection caused a massive change in regulation of liver transcripts, with robust up-regulation of genes involved in the antiviral response, indicating that the innate immune response functions in the host defense against Ad5 infection of the liver. The data and novel platforms developed in this study will facilitate further development of this important animal model.
has issue date	2015-11-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.07.024
bibo:pmid	26319212
has license	els-covid
sha1sum (hex)	4a1473dff62b4a5607cc52a3724756438f0c8af3
schema:url	https://doi.org/10.1016/j.virol.2015.07.024
resource representing a document's title	Transcriptome sequencing and development of an expression microarray platform for liver infection in adenovirus type 5-infected Syrian golden hamsters
has PubMed Central identifier	PMC4619110
has PubMed identifier	26319212
schema:publication	Virology
resource representing a document's body	covid:4a1473dff62b4a5607cc52a3724756438f0c8af3#body_text
is schema:about of	named entity 'intravenous' named entity 'liver' named entity 'response' named entity 'golden' named entity 'development' named entity 'infected' named entity 'MICROARRAY PLATFORM' named entity 'STIMULATED' named entity 'FOLLOWING' named entity 'IDENTIFIED' named entity 'PLATFORM' named entity 'MASSIVE' named entity 'DEVELOPMENT' named entity 'DISEASES' named entity 'USED' named entity 'ATTRACTIVE' named entity 'SYRIAN GOLDEN HAMSTER' named entity 'FUNCTIONS' named entity 'ANIMAL MODEL' named entity 'CAUSED' named entity 'TO INVESTIGATE' named entity 'DATA' named entity 'CHANGE IN' named entity 'GENES' named entity 'BASED' named entity 'NEW' named entity 'REPORT' named entity 'SYRIAN HAMSTER' named entity 'TISSUES' named entity 'ADENOVIRUS TYPE 5' named entity 'IMPORTANT' named entity 'INFECTIOUS DISEASES' named entity 'AD5' named entity 'REGULATION' named entity 'SEQUENCING' named entity 'INVOLVED' named entity 'ANTIVIRAL RESPONSE' named entity 'INNATE IMMUNE RESPONSE' covid:arg/4a1473dff62b4a5607cc52a3724756438f0c8af3 named entity 'HERE' named entity 'REDUNDANT' named entity 'OUR' named entity 'INFECTION' named entity 'UNIQUE' named entity 'CUSTOM' named entity 'LIVER INFECTION' named entity 'SYRIAN GOLDEN HAMSTERS' named entity 'DEVELOPMENT' named entity 'INFECTED' named entity 'TRANSCRIPTOME SEQUENCING' named entity 'DATA SET' named entity 'TRANSCRIPTOME' named entity 'LIVER' named entity 'STUDY' named entity 'NOVEL' named entity 'HOST DEFENSE' named entity 'UP-REGULATION' named entity 'INCLUDE' named entity 'LIPOPOLYSACCHARIDE' named entity 'ANIMAL' named entity 'RESPONSE' named entity 'GENERATED' named entity 'FOUND' named entity 'ROBUST' named entity 'HAMSTER' named entity 'TRANSCRIPTS' named entity 'POOLED' named entity 'INTRAVENOUS' named entity 'FOR RESEARCH' named entity 'ANNOTATION' named entity 'ASSEMBLY' named entity 'EXPRESSION MICROARRAY' named entity 'ADENOVIRUS TYPE 5' named entity 'INDICATING' named entity 'NON-' named entity 'TRANSCRIPTIONAL' named entity 'MICROARRAY'

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