About: Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats()

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About: Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats()
Creator	Farsang, Attila Szeredi, Levente Dori, Zá Dá M Bá Lint, Á Ndor Belá, Sá
source	Elsevier; Medline; PMC
abstract	Feline infectious peritonitis virus (FIPV) is a major pathogen of Felidae. Despite the extensive efforts taken in the past decades, development of the “ideal” live attenuated FIPV vaccine was not successful yet. In the present study, we provide data of immunisation experiments with a recombinant FCoV pair differing only in the truncation (PBFIPV-DF-2) or completion (PBFIPV-DF-2-R3i) of their ORF3abc regions. In our previous in vivo studies, these viruses proved to show the characters of low virulent or avirulent FCoV phenotypes, respectively. Therefore, we hypothesised the ability of these viruses, as possible vaccine candidates, in conferring protection in specific pathogen free (SPF) Domestic Shorthair as well as in conventional purebred British Shorthair cats. In SPF cats, after two oronasal and two intramuscular vaccinations with two weeks intervals, both vaccine candidates provided 100% protection against lethal homologous challenge with the highly virulent FIPV DF-2 strain. In contrast, the conventional purebred British Shorthair cats did not develop protection when they were immunised with the same vaccination regimes. In these groups 100% of the PBFIPV-DF-2-R3i immunised animals developed antibody-dependent enhancement (ADE). Prolonged survival was observed in 40% of the animals, while 60% showed fulminant disease course. Genetic and more probably immunological differences between the SPF and non-SPF purebred kittens can explain the different outcome of the vaccination experiment. Our data highlight the diverse immune responses between SPF and conventional cats and suggest a decisive role of previous infection by heterologous causative agents in the outcome of the vaccination against FIP.
has issue date	2014-03-14(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2013.10.015
bibo:pmid	24513277
has license	no-cc
sha1sum (hex)	4a16d8faf320e92f3717a0caa71bc1c9c0b7ce44
schema:url	https://doi.org/10.1016/j.vetmic.2013.10.015
resource representing a document's title	Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats()
has PubMed Central identifier	PMC7117248
has PubMed identifier	24513277
schema:publication	Vet Microbiol
resource representing a document's body	covid:4a16d8faf320e92f3717a0caa71bc1c9c0b7ce44#body_text
is schema:about of	named entity 'CATS' named entity 'BUT' named entity 'CORONAVIRUSES' named entity 'PROTECTION' named entity 'FELINE' named entity 'SPF' named entity 'CONVENTIONAL' named entity 'RECOMBINANT' named entity 'VACCINE' named entity 'Swedish Kennel Club' named entity 'FIP' named entity 'early death' named entity 'tissue culture' named entity 'DF-2' named entity 'antibody response' named entity 'pathogen' named entity 'FIP' named entity 'DF-2' named entity 'GenBank' named entity 'homologous' named entity 'Felis catus' named entity 'specific pathogen free' named entity 'FIPV' named entity 'Vaccination' named entity 'animal experiments' named entity 'FIP' named entity 'vaccine' named entity 'antibody' named entity '1:160' named entity 'recombination' named entity 'FCoV' named entity 'PBS' named entity 'SPF' named entity 'body weight' named entity 'titration' named entity 'immunological response' named entity 'cytopathic effect' named entity 'FIP' named entity 'virulent' named entity 'FIPV' named entity 'intramuscular injections' named entity 'recombination process' named entity 'immunisation' named entity 'Dengue' named entity 'follow-up studies' named entity 'lymphopenia' named entity 'Domestic Shorthair' named entity 'fulminant' named entity 'Qiagen' named entity 'phosphate buffered saline' named entity 'immunised' named entity 'immunisation' named entity 'feline calicivirus' named entity 'British Shorthair' named entity 'FIPV' named entity 'virus' named entity 'immune response' named entity 'DF-2' named entity 'colostrum' named entity 'infection' named entity 'lung' named entity 'weight loss' named entity 'DNA vaccination' named entity 'feline parvovirus' named entity 'plasma' named entity 'clinical signs' named entity 'Post-mortem examinations' named entity 'clinical signs' named entity 'SPF' named entity 'SPF' named entity 'homologous' named entity 'virulent' named entity 'vaccine' named entity 'control group' named entity 'virulent' named entity 'viruses' named entity 'Seroconversion'

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