About: The Clinical and Radiological Manifestations in Coronavirus Disease (COVID-19) with Negative Nucleic Acid Results

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Clinical and Radiological Manifestations in Coronavirus Disease (COVID-19) with Negative Nucleic Acid Results
Creator	Zhao, Hong Liu, Jun Sheng, Jifang Xu, Kaijin Lang, Guanjing Su, Junwei Wu, Wenrui Yin, Michael Lou, Haiyan Ren, Cheng Shen, Xiaomin Ying, Shihong
source	Medline; PMC
abstract	BACKGROUND: COVID-19 was a new emerging disease with high infectiousness. Its diagnosis primarily depended on real time-polymerase chain reaction (RT-PCR) results. This study investigated epidemiological, clinical and radiological characteristics of COVID-19 with negative RT-PCR results before confirmation. METHODS: COVID-19 patients were enrolled and divided into two groups, negative group with negative RT-PCR results before confirmation and positive group with positive results at the first detection. Epidemiological and clinical features were compared. Dynamic chest CT images of negative group were evaluated. RESULT: Nighty-nine laboratory-confirmed COVID-19 including eight patients (8%) with negative RT-PCR results were included. Patients from negative group had similar epidemiological features as the average age (50.25±13.27 y in the negative group and 53.70±16.64 y in the positive group) and gender distribution (males made up 50% of the negative group and 62.6% of the positive group) were comparable. No significant difference of clinical symptoms were observed between the two groups. It was found that fever was the most common symptom for both groups, followed by cough, expectoration, chest distress, fatigue and gastroenterological symptoms. Moreover, ground-glass opacities and consolidations were main manifestations in chest CT of COVID-19 patients with or without confirmed RT-PCR results. CONCLUSIONS: Regardless of initial RT-PCR results, COVID-19 patients had similar epidemiological, clinical and chest CT features. Our study suggested values of early chest CT scan in COVID-19 screening and dynamic significance of radiology in disease monitoring to guide clinical decision.
has issue date	2020-06-25(xsd:dateTime)
bibo:doi	10.1093/ofid/ofaa252
bibo:pmid	32704513
has license	cc-by-nc-nd
sha1sum (hex)	4a288a498709b5f251eabba22c46d850b3d89556
schema:url	https://doi.org/10.1093/ofid/ofaa252
resource representing a document's title	The Clinical and Radiological Manifestations in Coronavirus Disease (COVID-19) with Negative Nucleic Acid Results
has PubMed Central identifier	PMC7337757
has PubMed identifier	32704513
schema:publication	Open Forum Infect Dis
resource representing a document's body	covid:4a288a498709b5f251eabba22c46d850b3d89556#body_text
is schema:about of	named entity 'INFECTIOUSNESS' named entity 'RT-PCR' named entity 'GGO' named entity 'Coronavirus Disease' named entity 'lung' named entity 'lobular' named entity 'laboratory tests' named entity '85%' named entity 'sampling' named entity 'RT-PCR' named entity 't-test' named entity 'nucleic acid' named entity 'early diagnosis' named entity 'lung' named entity 'human infection' named entity 'demographic features' named entity 'viral replication' named entity 'COVID' named entity 'non-specific' named entity 'Chest CT' named entity 'COVID' named entity 'follow-up' named entity 'GGO' named entity 'RT-PCR test' named entity 'health crisis' named entity 'SARS-CoV-2' named entity 'pulmonary vein' named entity 'respiratory symptoms' named entity 'fever' named entity 'COVID' named entity 'epidemiological' named entity 'pleural' named entity 'severe acute respiratory syndrome' named entity 'sampling' named entity 'gastroenterological' named entity 'fever' named entity 'Wuhan' named entity 'pharyngeal' named entity 'nasopharyngeal' named entity 'loss of life' named entity 'COVID' named entity 'bronchoscopy' named entity 'sputum' named entity 'quarantine' named entity 'pleural' named entity 'GGO' named entity 'bronchial wall thickening' named entity 'community-acquired pneumonia' named entity 'oropharynx' named entity 'incubation' named entity 'left lung' named entity 'lower respiratory tract' named entity 'radiologists' named entity 'RT-PCR' named entity 'GGO' named entity 'viral infections' named entity 'pleural' named entity 'clinical features' named entity 'clinical outcome' named entity 'SARS' named entity 'RT-PCR' named entity 'dry cough' named entity 'COVID' named entity 'lymphopenia' named entity 'hyperactivity' named entity 'nodules' named entity 'COVID' named entity 'risk of transmission' named entity 'COVID' named entity 'respiratory illness'

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