About: Influenza A (H10N7) Virus Causes Respiratory Tract Disease in Harbor Seals and Ferrets

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Influenza A (H10N7) Virus Causes Respiratory Tract Disease in Harbor Seals and Ferrets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Influenza A (H10N7) Virus Causes Respiratory Tract Disease in Harbor Seals and Ferrets
Creator	Fouchier, Ron Kuiken, Thijs Osterhaus, Albert Koopmans, Marion Herfst, Sander Baumgärtner, Wolfgang Wohlsein, Peter Bodewes, Rogier Richard, Mathilde Seehusen, Frauke Herbst, Werner Bestebroer, Theo Lehnert, Kristina Lexmond, Pascal Prenger-Berninghoff, Ellen Puff, Christina Siebert, Ursula Pfankuche, Vanessa Van De Bildt, Marco Van Den Brand, Judith
source	PMC
abstract	Avian influenza viruses sporadically cross the species barrier to mammals, including humans, in which they may cause epidemic disease. Recently such an epidemic occurred due to the emergence of avian influenza virus of the subtype H10N7 (Seal/H10N7) in harbor seals (Phoca vitulina). This epidemic caused high mortality in seals along the north-west coast of Europe and represented a potential risk for human health. To characterize the spectrum of lesions and to identify the target cells and viral distribution, findings in 16 harbor seals spontaneously infected with Seal/H10N7 are described. The seals had respiratory tract inflammation extending from the nasal cavity to bronchi associated with intralesional virus antigen in respiratory epithelial cells. Virus infection was restricted to the respiratory tract. The fatal outcome of the viral infection in seals was most likely caused by secondary bacterial infections. To investigate the pathogenic potential of H10N7 infection for humans, we inoculated the seal virus intratracheally into six ferrets and performed pathological and virological analyses at 3 and 7 days post inoculation. These experimentally inoculated ferrets displayed mild clinical signs, virus excretion from the pharynx and respiratory tract inflammation extending from bronchi to alveoli that was associated with virus antigen expression exclusively in the respiratory epithelium. Virus was isolated only from the respiratory tract. In conclusion, Seal/H10N7 infection in naturally infected harbor seals and experimentally infected ferrets shows that respiratory epithelial cells are the permissive cells for viral replication. Fatal outcome in seals was caused by secondary bacterial pneumonia similar to that in fatal human cases during influenza pandemics. Productive infection of ferrets indicates that seal/H10N7 may possess a zoonotic potential. This outbreak of LPAI from wild birds to seals demonstrates the risk of such occasions for mammals and thus humans.
has issue date	2016-07-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0159625
bibo:pmid	27448168
has license	cc-by
sha1sum (hex)	4a4829a678305f54711666d194597971627c7b48
schema:url	https://doi.org/10.1371/journal.pone.0159625
resource representing a document's title	Influenza A (H10N7) Virus Causes Respiratory Tract Disease in Harbor Seals and Ferrets
has PubMed Central identifier	PMC4957826
has PubMed identifier	27448168
schema:publication	PLoS One
resource representing a document's body	covid:4a4829a678305f54711666d194597971627c7b48#body_text
is schema:about of	named entity 'potential' named entity 'performed' named entity 'target cells' named entity 'inoculated' named entity 'ferrets' covid:arg/4a4829a678305f54711666d194597971627c7b48 named entity 'These' named entity 'zoonotic' named entity 'viral' named entity 'high' named entity 'antigen' named entity 'viral infection' named entity 'harbor seals' named entity 'risk' named entity 'virus' named entity 'investigate' named entity 'epidemic' named entity 'respiratory' named entity 'lesions' named entity 'epidemic' named entity 'restricted' named entity 'virus' named entity 'infected' named entity 'H10N7' named entity 'respiratory tract' named entity 'inflammation' named entity 'inflammation' named entity 'epidemic' named entity 'antigen' named entity 'clinical signs' named entity 'human health' named entity 'Europe' named entity 'influenza' named entity 'alveoli' named entity 'Phoca vitulina' named entity 'spontaneously infected' named entity 'H10N7' named entity 'avian influenza virus' named entity 'bronchi' named entity 'Virus infection' named entity 'Virus' named entity 'H10N7' named entity 'spp' named entity 'virus' named entity 'harbor seals' named entity 'plasma cells' named entity 'virus' named entity 'virus' named entity 'lungs' named entity 'inoculation' named entity 'The Netherlands' named entity 'excreted' named entity 'infection' named entity 'virulent' named entity 'influenza' named entity 'Virus' named entity 'H10N7' named entity 'influenza virus' named entity 'virus' named entity 'Neisseria' named entity 'bacterial infection' named entity 'hypertrophy'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software