About: Antiviral Decoction of Isatidis Radix (板藍根 bǎn lán gēn) Inhibited Influenza Virus Adsorption on MDCK Cells by Cytoprotective Activity

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About: Antiviral Decoction of Isatidis Radix (板藍根 bǎn lán gēn) Inhibited Influenza Virus Adsorption on MDCK Cells by Cytoprotective Activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Decoction of Isatidis Radix (板藍根 bǎn lán gēn) Inhibited Influenza Virus Adsorption on MDCK Cells by Cytoprotective Activity
Creator	Ke, Lijing Rao, Pingfan Wen, Teng Zhou, Jianwu Bradshaw, Jeremy Pingfan, Rao
Source	Elsevier
abstract	Abstract The aim of this study is to elucidate how the Isatidis Radix (板藍根 bǎn lán gēn) tonic, as an aqueous mixture of hundreds of compositions, interrupts the infection of influenza viruses to their host cells. The efficacy of the tonic was evaluated and expressed as cell proliferation rate and plaque reduction rate in Madin-Darby Canine Kidney (MDCK) cells, against 3 strains of influenza A and B viruses. This boiling water (at 100°C) extract of Isatidis Radix (RIE) showed antiviral activity against influenza virus A and B. The concentration for 50% inhibition of influenza virus A replication (IC50) in MDCK cell was 12.6mg/mL with a therapeutic index >8. When cells were incubated with RIE prior to virus adsorption, the numbers of viable cell were at least doubled compared to the numbers of virus control, RIE incubation after virus adsorption and RIE incubation with virus prior to adsorption, in both influenza virus A and B. Moreover, much less virus particles were spotted by scanning electron microscope (SEM) in the RIE pre-treated cells than the cells without RIE treatment. These results indicate the antiviral activity of RIE is mainly attributed to its host cell protection effect but not actions on virus or post-virus-adsorption interruption. Cell, but not virus, is more likely to be the action target of RIE.
has issue date	2012-03-31(xsd:dateTime)
bibo:doi	10.1016/s2225-4110(16)30070-0
has license	els-covid
sha1sum (hex)	4a8020a12f136e76f25638107261d4f5a3148514
schema:url	https://doi.org/10.1016/s2225-4110%2816%2930070-0
resource representing a document's title	Antiviral Decoction of Isatidis Radix (板藍根 bǎn lán gēn) Inhibited Influenza Virus Adsorption on MDCK Cells by Cytoprotective Activity
schema:publication	Journal of Traditional and Complementary Medicine
resource representing a document's body	covid:4a8020a12f136e76f25638107261d4f5a3148514#body_text
is schema:about of	named entity 'influenza' named entity 'cell proliferation' named entity 'Adsorption' named entity 'ACTIVITY' named entity 'INFLUENZA VIRUS A' named entity 'VIRUSES' named entity 'DECOCTION' named entity 'AIM' named entity 'CELLS' named entity 'VIRUS PARTICLES' named entity 'INFLUENZA A' named entity 'INFLUENZA VIRUS A AND B' named entity 'DOUBLED' named entity 'EFFECT' named entity 'CONTROL' named entity 'PLAQUE' named entity '100%' covid:arg/4a8020a12f136e76f25638107261d4f5a3148514 named entity 'CELL PROLIFERATION RATE' named entity 'NUMBERS' named entity 'CONCENTRATION' named entity 'COMPARED' named entity 'INTERRUPTS' named entity 'MDCK CELL' named entity 'COMPOSITIONS' named entity 'RESULTS' named entity 'EXPRESSED' named entity 'ADSORPTION' named entity 'STRAINS' named entity 'HOST CELL' named entity 'CYTOPROTECTIVE' named entity 'ADSORPTION' named entity 'MDCK CELLS' named entity 'REDUCTION RATE' named entity 'ACTION' named entity 'MG%' named entity 'HOST CELLS' named entity 'ISATIDIS RADIX' named entity 'RIE' named entity 'ISATIDIS RADIX' named entity 'INHIBITED' named entity 'INFLUENZA VIRUS' named entity 'ANTIVIRAL' named entity 'HOW' named entity '50%' named entity 'ANTIVIRAL ACTIVITY' named entity 'PRE' named entity 'AQUEOUS' named entity 'VIABLE CELL' named entity 'EFFICACY' named entity 'EVALUATED' named entity '12.6' named entity 'THEIR' named entity 'INFLUENZA VIRUSES' named entity 'REPLICATION' named entity 'TREATMENT' named entity 'MUCH' named entity 'VIRUS' named entity 'KIDNEY' named entity 'SCANNING ELECTRON MICROSCOPE' named entity 'ITS' named entity 'BUT' named entity 'SPOTTED' named entity 'CELL' named entity 'CELL PROTECTION' named entity 'POST' named entity 'TONIC' named entity 'TREATED' named entity 'PRIOR TO' named entity 'THERAPEUTIC INDEX' named entity 'THESE' named entity 'EXTRACT' named entity 'ACTIONS' named entity 'TARGET' named entity 'CANINE' named entity 'INFECTION' named entity 'INCUBATION' named entity 'INTERRUPTION' named entity 'LIKELY'

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