About: Hepatitis E virus infection during pregnancy

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hepatitis E virus infection during pregnancy
Creator	Wu, Chunchen Wu, Xiaoxue Xia, Jianbo
source	Medline; PMC
abstract	BACKGROUND: Hepatitis E virus (HEV) generally causes self-limiting viral hepatitis. However, in pregnant women, HEV infection can be severe and has been associated with up to 30% mortality in the third trimester. Additionally, HEV infection in pregnancy is also associated with high rates of preterm labor and vertical transmission. MAIN BODY: HEV is now recognized as a global health problem in both developing and industrialized countries. HEV can be transmitted via the fecal-oral route, zoonotic route, and blood transfusion route. An altered immune status, hormonal levels, and viral factors may be related to the severity of the disease. Currently, no established treatment is available for HEV in pregnant women. A Chinese vaccine has been demonstrated to be protective against HEV in the general population and seems to be safe in pregnancy; however, its safety and efficacy in a large population of pregnant women remain to be determined. CONCLUSION: This review summarizes the current knowledge about HEV infection during pregnancy and focuses on the epidemiology, clinical manifestations, mechanisms underlying severe liver injury, and management and prevention of HEV infection during pregnancy. Considering that HEV infection during pregnancy may result in poor outcomes, screening for and monitoring HEV infection early in pregnancy should be taken into account. In addition, a better understanding of the pathogenesis will help to develop potential treatment strategies targeting HEV infection in pregnancy.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.1186/s12985-020-01343-9
bibo:pmid	32522266
has license	cc-by
sha1sum (hex)	4a97873edfdd9e85503d682666c89b71719f9c3a
schema:url	https://doi.org/10.1186/s12985-020-01343-9
resource representing a document's title	Hepatitis E virus infection during pregnancy
has PubMed Central identifier	PMC7286216
has PubMed identifier	32522266
schema:publication	Virol J
resource representing a document's body	covid:4a97873edfdd9e85503d682666c89b71719f9c3a#body_text
is schema:about of	named entity 'body' named entity 'safety' named entity 'HEV' named entity 'viral' named entity 'However' named entity 'HEV' named entity 'Main' named entity 'pregnancy' named entity 'zoonotic' named entity 'problem' named entity 'DISEASE' named entity 'SEVERE' named entity 'COUNTRIES' named entity 'UNDERSTANDING' named entity 'UP TO' named entity 'KNOWLEDGE' named entity 'TAKEN' named entity 'SEVERE LIVER INJURY' named entity 'CONSIDERING' named entity 'MECHANISMS' named entity 'screening' named entity 'generally' named entity 'mortality' named entity 'HEV' named entity 'vaccine' named entity 'pregnancy' named entity 'infection' named entity 'trimester' named entity 'Hepatitis E virus' named entity 'Conclusion' named entity 'liver injury' named entity 'infection' named entity 'infection' named entity 'Hepatitis E virus' named entity 'HEV' named entity 'general population' named entity 'HEV' named entity 'pregnancy' named entity 'preterm labor' named entity 'industrialized countries' named entity 'epidemiology' named entity 'pregnancy' named entity 'infection' named entity 'pregnancy' named entity 'HEV' named entity 'HEV' named entity 'IFN' named entity 'HEV' named entity 'Th1' named entity 'HEV' named entity 'interferon-α' named entity 'innate immune responses' named entity 'HCV' named entity 'cirrhosis' named entity 'infection' named entity 'Th2' named entity 'TGF-β1' named entity 'nucleoside analogs' named entity 'fulminant hepatic failure' named entity 'phosphoprotein' named entity 'vertical transmission' named entity 'virulence' named entity 'ORF1' named entity 'fetus' named entity 'coagulopathy' named entity 'ORF2' named entity 'HEV' named entity 'IRF3' named entity 'ORF2' named entity 'fulminant hepatitis' named entity 'HEV' named entity 'fulminant hepatitis' named entity 'vertically transmitted' named entity 'viral entry' named entity 'HEV' named entity 'pregnancy' named entity 'pregnant women' named entity 'nutritional status' named entity 'HEV'

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