About: Hydropathic characteristics of adenovirus hexons

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hydropathic characteristics of adenovirus hexons
Creator	Li, Q.-G Lindman, K Wadell, G
Source	Medline; PMC
abstract	The complete nucleotide sequence and the predicted amino acid sequence of the adenovirus type 7 hexon gene were determined. The hydro-pathy of the hexon proteins from human adenovirus types 2, 3, 4, 5, 7, 12, 16, 40, 41, and 48, bovine adenovirus type 3, murine adenovirus type 1, and avian adenovirus types 1 and 10 was analysed. The presence of purines and pyrimid-ines in the second position of the codons was correlated to hydrophilicity and hydrophobicity, respectively. Comparison of the hydrophilicity plots of eight hexons showed seven hypervariable regions to be distributed on the surface. A large portion of the hypervariable regions manifests hydrophilicity. The strength of the surface charge accumulated on the hydrophilic and hydrophobic regions correlated to the tissue tropism of the different adenovirus types. Analysis of codon usage for adenovirus hexons showed that among synony-mous codons those with cytidine in the third position were preferably used to a great extent. Analysis of the nucleotide and amino acid sequence pair distances and the phylogenetic tree of 14 hexon proteins showed members of subgenera B, D and E to be closely related, especially Ad4 and Ad16, and subgenus A to be closely related to subgenus F.
has issue date	1997-07-01(xsd:dateTime)
bibo:doi	10.1007/s007050050162
bibo:pmid	9267445
has license	no-cc
sha1sum (hex)	4acc93d79bf6e7caf784e9eba57cce742b32a3f1
schema:url	https://doi.org/10.1007/s007050050162
resource representing a document's title	Hydropathic characteristics of adenovirus hexons
has PubMed Central identifier	PMC7087114
has PubMed identifier	9267445
schema:publication	Arch Virol
resource representing a document's body	covid:4acc93d79bf6e7caf784e9eba57cce742b32a3f1#body_text
is schema:about of	named entity 'nucleotide' named entity 'The presence' named entity 'predicted' named entity 'type 3' named entity 'tissue tropism' named entity 'NUCLEOTIDE' named entity 'COMPLETE' named entity 'pyrimidines' named entity 'cytidine' named entity 'purines' named entity 'hydrophilicity' named entity 'analysed' named entity 'pair' named entity 'types' named entity 'acid' named entity 'complete' named entity 'hexon' named entity 'codons' named entity 'gene' named entity 'adenovirus' named entity 'pyrimidines' named entity 'codon usage' named entity 'hydrophobic regions' named entity 'hydrophilicity' named entity 'hydrophilic' named entity 'hexon' named entity 'amino acid sequence' named entity 'Hydropathic' named entity 'accumulated' named entity 'Aviadenovirus' named entity 'hexon' named entity 'serotypes' named entity 'hydrophilic' named entity 'genome' named entity 'hexon' named entity 'cytidine' named entity 'nonpolar' named entity 'hexon' named entity 'nucleotides' named entity 'hexons' named entity 'adenoviruses' named entity 'Adenovirus' named entity 'protein' named entity 'codon usage' named entity 'cytidine' named entity 'hypervariable region' named entity 'deletions' named entity 'hexons' named entity 'amino acids' named entity 'protein sequence' named entity 'Kyte-Doolittle' named entity 'hydropathy' named entity 'Gln' named entity 'Sweden' named entity 'Ad5' named entity 'Stockholm County Council' named entity 'hexon' named entity 'nucleotide sequences' named entity 'hydropathy' named entity 'molecule' named entity 'hexon' named entity 'hydrophilic' named entity 'hydrophilicity' named entity 'type 1' named entity 'Sweden' named entity 'surface charge' named entity 'sequence data' named entity 'peptide' named entity 'amino acid sequence homology' named entity 'host species' named entity 'hydropathy' named entity 'guanine' named entity 'hydrophilic' named entity 'Mastadenovirus' named entity 'Lys' named entity 'hydrophobic regions' named entity 'hydropathy' named entity 'antigenic determinants' named entity 'gene'

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