About: Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review

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About: Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review
Creator	Kirsch, Matthias Liaudet, Lucas Marcucci, Carlo Roumy, Aurélien Rusca, Marco
Source	PMC
abstract	Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology that provides transient respiratory and circulatory support for patients with profound cardiogenic shock or refractory cardiac arrest. Among its potential complications, VA-ECMO may adversely affect lung function through various pathophysiological mechanisms. The interaction of blood components with the biomaterials of the extracorporeal membrane elicits a systemic inflammatory response which may increase pulmonary vascular permeability and promote the sequestration of polymorphonuclear neutrophils within the lung parenchyma. Also, VA-ECMO increases the afterload of the left ventricle (LV) through reverse flow within the thoracic aorta, resulting in increased LV filling pressure and pulmonary congestion. Furthermore, VA-ECMO may result in long-standing pulmonary hypoxia, due to partial shunting of the pulmonary circulation and to reduced pulsatile blood flow within the bronchial circulation. Ultimately, these different abnormalities may result in a state of persisting lung inflammation and fibrotic changes with concomitant functional impairment, which may compromise weaning from VA-ECMO and could possibly result in long-term lung dysfunction. This review presents the mechanisms of lung damage and dysfunction under VA-ECMO and discusses potential strategies to prevent and treat such alterations.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1186/s13054-020-02937-z
bibo:pmid	32393326
has license	cc-by
sha1sum (hex)	4b13cd0f4c9499362fdee43b64d24eb13de46ba1
schema:url	https://doi.org/10.1186/s13054-020-02937-z
resource representing a document's title	Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review
has PubMed Central identifier	PMC7216520
has PubMed identifier	32393326
schema:publication	Crit Care
resource representing a document's body	covid:4b13cd0f4c9499362fdee43b64d24eb13de46ba1#body_text
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