About: Legume Lectins Inhibit Human Parainfluenza Virus Type 2 Infection by Interfering with the Entr

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Legume Lectins Inhibit Human Parainfluenza Virus Type 2 Infection by Interfering with the Entr
Creator	Kawano, Mitsuo Komada, Hiroshi Tsurudome, Masato Kihira, Sahoko Koyama, Aoi Takano, Sayaka Tanemura, Miho Uematsu, Jun Ura, Yukari Yamamoto, Hidetaka O'brien, Myles
source	Medline; PMC
abstract	Three lectins with different sugar binding specificities were investigated for anti-viral activity against human parainfluenza virus type 2 (hPIV-2). The lectins, concanavalin A (Con A), lens culinaris agglutinin (LCA) and peanut agglutinin (PNA), inhibited cell fusion and hemadsorption induced by hPIV-2. Virus nucleoprotein (NP) gene synthesis was largely inhibited, but fusion (F) and hemagglutinin-neuraminidase (HN) gene syntheses were not. An indirect immunofluorescence study showed that Con A inhibited virus NP, F and HN protein syntheses, but LCA did not completely inhibit them, and that PNA inhibited only NP protein synthesis. Using a recombinant green fluorescence protein-expressing hPIV-2, without matrix protein (rghPIV-2ΔM), it was found that virus entry into the cells was not completely prevented. The lectins considerably reduced the number of viruses released compared with that of virus infected cells. The lectins bound to cell surface within 10 min, and many aggregates were observed at 30 min. Con A and LCA slightly disrupted actin microfilaments and microtubules, but PNA had almost no effect on them. These results indicated that the inhibitory effects of the lectins were caused mainly by the considerable prevention of virus adsorption to the cells by the lectin binding to their receptors.
has issue date	2012-06-29(xsd:dateTime)
bibo:doi	10.3390/v4071104
bibo:pmid	22852043
has license	cc-by
sha1sum (hex)	4b3ddd160ebda77b58843d167709d71a73a3bf4a
schema:url	https://doi.org/10.3390/v4071104
resource representing a document's title	Legume Lectins Inhibit Human Parainfluenza Virus Type 2 Infection by Interfering with the Entr
has PubMed Central identifier	PMC3407897
has PubMed identifier	22852043
schema:publication	Viruses
resource representing a document's body	covid:4b3ddd160ebda77b58843d167709d71a73a3bf4a#body_text
is schema:about of	named entity 'HUMAN PARAINFLUENZA VIRUS TYPE 2' named entity 'VIRAL ACTIVITY' named entity 'SPECIFICITIES' named entity 'INVESTIGATED' named entity 'LECTINS' named entity 'ENTRY' named entity 'DIFFERENT' named entity 'LEGUME' named entity 'HUMAN PARAINFLUENZA VIRUS TYPE 2' named entity 'INTERFERING' named entity 'SUGAR BINDING' named entity 'INFECTION' named entity 'LECTINS' named entity 'human parainfluenza virus' named entity 'type 2' named entity 'Human Parainfluenza Virus' named entity 'actin microfilaments' named entity 'culture medium' named entity 'Rubulavirus' named entity 'Invitrogen' named entity 'cell surface' named entity 'recombinant virus' named entity 'PNA' named entity 'sugar' named entity 'rhodamine' named entity 'virus' named entity 'morphology' named entity 'mannose' named entity 'RNA' named entity 'Glucose' named entity 'gene' named entity 'Sendai virus' named entity 'protein' named entity 'transcription' named entity 'mannose-binding lectins' named entity 'chimeric' named entity 'kidney' named entity 'lectin' named entity 'binding proteins' named entity 'FCS' named entity 'PBS' named entity 'Human parainfluenza virus' named entity 'infection' named entity 'mAbs' named entity 'Japan' named entity 'Actin' named entity 'light microscope' named entity 'virus' named entity 'lectins' named entity 'Alexa 488' named entity 'fucose' named entity 'genus' named entity 'formaldehyde' named entity 'PCR' named entity 'protein' named entity 'Tokyo' named entity 'Paramyxoviridae' named entity 'Actin' named entity 'Tubulin' named entity 'lectins' named entity 'indirect immunofluorescence' named entity 'lectins' named entity 'non-specific' named entity 'protein' named entity 'cytoskeleton' named entity 'titer' named entity 'virus' named entity 'virus' named entity 'primers' named entity 'protein expression' named entity 'recombinant virus'

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