About: SARS coronavirus protein 7a interacts with human Ap(4)A-hydrolase

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About: SARS coronavirus protein 7a interacts with human Ap(4)A-hydrolase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS coronavirus protein 7a interacts with human Ap(4)A-hydrolase
Creator	Zakhartchouk, Alexander Moshynskyy, Igor Vasilenko, Natalia
Source	Medline; PMC
abstract	The SARS coronavirus (SARS-CoV) open reading frame 7a (ORF 7a) encodes a 122 amino acid accessory protein. It has no significant sequence homology with any other known proteins. The 7a protein is present in the virus particle and has been shown to interact with several host proteins; thereby implicating it as being involved in several pathogenic processes including apoptosis, inhibition of cellular protein synthesis, and activation of p38 mitogen activated protein kinase. In this study we present data demonstrating that the SARS-CoV 7a protein interacts with human Ap(4)A-hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17). Ap(4)A-hydrolase is responsible for metabolizing the %22allarmone%22 nucleotide Ap(4)A and therefore likely involved in regulation of cell proliferation, DNA replication, RNA processing, apoptosis and DNA repair. The interaction between 7a and Ap(4)A-hydrolase was identified using yeast two-hybrid screening. The interaction was confirmed by co-immunoprecipitation from cultured human cells transiently expressing V5-His tagged 7a and HA tagged Ap(4)A-hydrolase. Human tissue culture cells transiently expressing 7a and Ap(4)A-hydrolase tagged with EGFP and Ds-Red2 respectively show these proteins co-localize in the cytoplasm.
has issue date	2010-02-09(xsd:dateTime)
bibo:doi	10.1186/1743-422x-7-31
bibo:pmid	20144233
has license	cc-by
sha1sum (hex)	4b3e454f57edd89563485c04da1df5f95ebd2b5e
schema:url	https://doi.org/10.1186/1743-422x-7-31
resource representing a document's title	SARS coronavirus protein 7a interacts with human Ap(4)A-hydrolase
has PubMed Central identifier	PMC2831879
has PubMed identifier	20144233
schema:publication	Virol J
resource representing a document's body	covid:4b3e454f57edd89563485c04da1df5f95ebd2b5e#body_text
is schema:about of	named entity 'TISSUE CULTURE' named entity 'CELLS' named entity 'PROTEIN ' named entity 'IDENTIFIED' named entity 'VIRUS PARTICLE' named entity 'EC 3.6.1' named entity 'DNA REPAIR' named entity '1.17' named entity 'PROCESSES' named entity 'KNOWN' named entity 'CO-IMMUNOPRECIPITATION' named entity 'PROTEINS' named entity 'SIGNIFICANT' named entity 'INCLUDING' named entity 'HYDROLASE' named entity 'INTERACTION' named entity 'DNA REPLICATION' named entity 'APOPTOSIS' named entity 'RNA PROCESSING' named entity 'acid' named entity 'proteins' named entity 'virus' named entity 'protein' named entity 'data' named entity 'expressing' covid:arg/4b3e454f57edd89563485c04da1df5f95ebd2b5e named entity 'ACCESSORY PROTEIN' named entity 'LIKELY' named entity 'YEAST TWO-HYBRID' named entity 'CELLULAR' named entity 'SEQUENCE HOMOLOGY' named entity 'SARS-COV' named entity 'TWO-HYBRID SCREENING' named entity 'PROTEIN SYNTHESIS' named entity 'HUMAN CELLS' named entity 'HUMAN' named entity 'RESPONSIBLE' named entity 'REGULATION OF CELL PROLIFERATION' named entity 'PRESENT' named entity 'THESE' named entity 'DIADENOSINE TETRAPHOSPHATE' named entity 'HUMAN TISSUE' named entity 'SARS CORONAVIRUS' named entity 'HYDROLASE' named entity 'PROTEIN ' named entity 'P38 MITOGEN ACTIVATED PROTEIN KINASE' named entity 'EGFP' named entity 'BEING' named entity 'TO INTERACT WITH' named entity 'CULTURED' named entity 'USING' named entity 'NUCLEOTIDE' named entity 'STUDY' named entity 'TAGGED' named entity 'AMINO ACID' named entity 'HOST' named entity 'CONFIRMED BY' named entity 'OPEN READING FRAME' named entity 'SARS CORONAVIRUS' named entity 'HUMAN' named entity 'INHIBITION' named entity 'LOCALIZE' named entity 'CYTOPLASM' named entity 'DATA' named entity 'PATHOGENIC' named entity 'INVOLVED' named entity 'RED2' named entity 'ACTIVATION' named entity 'protein' named entity 'two-hybrid screening' named entity 'demonstrating' named entity 'processing' named entity 'responsible' named entity 'host' named entity 'proteins' named entity 'study' named entity 'EGFP' named entity 'mitogen' named entity 'inhibition'

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