About: Development of a Genetically–Engineered, Candidate Polio Vaccine Employing the Self–Assembling Properties of the Tobacco Mosaic Virus Coat Protein

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About: Development of a Genetically–Engineered, Candidate Polio Vaccine Employing the Self–Assembling Properties of the Tobacco Mosaic Virus Coat Protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of a Genetically–Engineered, Candidate Polio Vaccine Employing the Self–Assembling Properties of the Tobacco Mosaic Virus Coat Protein
Creator	Cunningham, Janet Garvin+, Robert Haynes, Joel Lennick, Michael Shen, Shi-Hsiang Von Seefried, Adolph
Source	Medline; PMC
abstract	A synthetic gene coding for the coat protein of tobacco mosaic virus (TMVCP) was expressed in E. coli under the direction of the lacUV5 promoter. Modification of the 3′ end of the TMVCP gene by insertion of a region coding for an antigenic epitope from poliovirus type 3 resulted in the production of a hybrid TMVCP (TMVCP–polio 3). Both the E. coli–produced TMVCP and TMVCP–polio 3 were shown to assemble into virus–like rods under acidic conditions in E. coli extracts. Their purification was accomplished in a single step by chromatography on Sepharose 6B. TMVCP–polio 3 induced the formation of poliovirus neutralizing antibodies following injection into rats. The level of immune response was related to the degree of polymerization of the TMVCP–polio 3 preparations.
has issue date	1986-01-01(xsd:dateTime)
bibo:doi	10.1038/nbt0786-637
bibo:pmid	32226216
has license	no-cc
sha1sum (hex)	4b4b9fa4b9877053028c87aea30e0674c88bb135
schema:url	https://doi.org/10.1038/nbt0786-637
resource representing a document's title	Development of a Genetically–Engineered, Candidate Polio Vaccine Employing the Self–Assembling Properties of the Tobacco Mosaic Virus Coat Protein
has PubMed Central identifier	PMC7097054
has PubMed identifier	32226216
schema:publication	Biotechnology (N Y)
resource representing a document's body	covid:4b4b9fa4b9877053028c87aea30e0674c88bb135#body_text
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