About: Interferon-Induced Transmembrane Protein–Mediated Inhibition of Host Cell Entry of Ebolaviruses

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-Induced Transmembrane Protein–Mediated Inhibition of Host Cell Entry of Ebolaviruses
Creator	Pöhlmann, Stefan Hoffmann, Markus Gnirß, Kerstin Winkler, Michael Wrensch, Florian Takada, Ayato Lu, Kai Simmons, Graham Karsten, Christina
Source	Medline; PMC
abstract	Ebolaviruses are highly pathogenic in humans and nonhuman primates and pose a severe threat to public health. The interferon-induced transmembrane (IFITM) proteins can restrict entry of ebolaviruses, influenza A viruses, and other enveloped viruses. However, the breadth and mechanism of the antiviral activity of IFITM proteins are incompletely understood. Here, we employed ebolavirus glycoprotein–pseudotyped vectors and ebolavirus-like particles to address this question. We show that IFITM proteins inhibit the cellular entry of diverse ebolaviruses and demonstrate that type I interferon induces IFITM protein expression in macrophages, major viral targets. Moreover, we show that IFITM proteins block entry of influenza A viruses and ebolaviruses by different mechanisms and provide evidence that antibodies and IFITM proteins can synergistically inhibit cellular entry of ebolaviruses. These results provide insights into the role of IFITM proteins in infection by ebolaviruses and suggest a mechanism by which antibodies, though poorly neutralizing in vitro, might contribute to viral control in vivo.
has issue date	2015-10-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jiv255
bibo:pmid	26034199
has license	cc-by-nc-nd
sha1sum (hex)	4b55b2415bd2adff96e6013f792d281693bf4587
schema:url	https://doi.org/10.1093/infdis/jiv255
resource representing a document's title	Interferon-Induced Transmembrane Protein–Mediated Inhibition of Host Cell Entry of Ebolaviruses
has PubMed Central identifier	PMC4564551
has PubMed identifier	26034199
schema:publication	J Infect Dis
resource representing a document's body	covid:4b55b2415bd2adff96e6013f792d281693bf4587#body_text
is schema:about of	named entity 'HUMANS' named entity 'EVIDENCE' named entity 'RESULTS' named entity 'UNDERSTOOD' named entity 'VIRUSES' named entity 'SEVERE' named entity 'EMPLOYED' named entity 'SUGGEST' named entity 'TRANSMEMBRANE' named entity 'PATHOGENIC' named entity 'INSIGHTS' named entity 'antibodies' named entity 'public health' named entity 'antibodies' named entity 'viruses' named entity 'Entry' named entity 'MECHANISM' named entity 'RESTRICT' named entity 'EBOLAVIRUS' named entity 'CELLULAR' named entity 'INFLUENZA A' named entity 'DIFFERENT' named entity 'PROTEIN EXPRESSION' named entity 'ADDRESS' named entity 'CONTRIBUTE ' named entity 'PUBLIC HEALTH' named entity 'ANTIVIRAL ACTIVITY' named entity 'MECHANISMS' named entity 'POORLY' named entity 'INTERFERON-INDUCED TRANSMEMBRANE PROTEIN' named entity 'INHIBITION' named entity 'CONTROL' named entity 'VECTORS' named entity 'HERE' named entity 'BREADTH' named entity 'INTERFERON' named entity 'THREAT' named entity 'TYPE I INTERFERON' named entity 'ENTRY' named entity 'MAJOR' named entity 'NONHUMAN PRIMATES' named entity 'INFECTION' named entity 'INDUCED' named entity 'VIRAL' named entity 'IN VIVO' named entity 'DIVERSE' named entity 'MEDIATED' named entity 'HOST CELL' named entity 'MACROPHAGES' named entity 'PARTICLES' named entity 'IN VITRO' named entity 'TARGETS' named entity 'LIKE' named entity 'PROTEINS' named entity 'BLOCK' named entity 'QUESTION' named entity 'POSE' named entity 'GLYCOPROTEIN' named entity 'ANTIBODIES' named entity 'ROLE' named entity 'THESE' named entity 'PROVIDE' named entity 'HIGHLY' named entity 'ENTRY' named entity 'pathogenic' named entity 'mechanism' named entity 'targets' named entity 'particles' named entity 'However' named entity 'type I interferon' named entity 'synergistically' named entity 'viral' named entity 'activity'

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