About: Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data

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About: Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data
Creator	Nahar, Lutfun Ali, S Uddin, Ali, Eunus Eunus, Islam, D Islam, Muhammad Rouf, Razina Sarker, Kumer Sarker, Satyajit Shaikh, Jamal Shilpi, Jamil Tiralongo, Evelin Uddin, Shaikh
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Garlic (Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its anti-viral effects and the underlying molecular mechanisms exists. SCOPE AND APPROACH: The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review. KEY FINDINGS AND CONCLUSIONS: Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1016/j.tifs.2020.08.006
bibo:pmid	32836826
has license	no-cc
sha1sum (hex)	4b823ad742a102c175893bd0db4b9896e6afbb77
schema:url	https://doi.org/10.1016/j.tifs.2020.08.006
resource representing a document's title	Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data
has PubMed Central identifier	PMC7434784
has PubMed identifier	32836826
schema:publication	Trends Food Sci Technol
resource representing a document's body	covid:4b823ad742a102c175893bd0db4b9896e6afbb77#body_text
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