About: LY6E impairs coronavirus fusion and confers immune control of viral disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	LY6E impairs coronavirus fusion and confers immune control of viral disease
Creator	Thiel, Volker Dijkman, Ronald Pöhlmann, Stefan Gallagher, Tom Hoffmann, Markus Fan, Wenchun Steinmann, Eike Todt, Daniel Kleine-Weber, Hannah Zimmer, Gert Stalder, Hanspeter Ebert, Nadine Pfaender, Stephanie Schoggins, John Saeed, Mohsan Hanners, Natasha Hirt, Dagny Hoffmann, H Kovski, Philip Kratzel, Annika Mar 4#, Katrina Michailidis, Eleftherios Rice, Charles Wight-Carter, Mary
Source	BioRxiv; MedRxiv; Medline
abstract	Zoonotic coronaviruses (CoVs) are significant threats to global health, as exemplified by the recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. Host immune responses to CoV are complex and regulated in part through antiviral interferons. However, the interferon-stimulated gene products that inhibit CoV are not well characterized2. Here, we show that interferon-inducible lymphocyte antigen 6 complex, locus E (LY6E) potently restricts cellular infection by multiple CoVs, including SARS-CoV, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV). Mechanistic studies revealed that LY6E inhibits CoV entry into cells by interfering with spike protein-mediated membrane fusion. Importantly, mice lacking Ly6e in hematopoietic cells were highly susceptible to murine CoV infection. Exacerbated viral pathogenesis in Ly6e knockout mice was accompanied by loss of hepatic and splenic immune cells and reduction in global antiviral gene pathways. Accordingly, we found that Ly6e directly protects primary B cells and dendritic cells from murine CoV infection. Our results demonstrate that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis. These findings advance our understanding of immune-mediated control of CoV in vitro and in vivo, knowledge that could help inform strategies to combat infection by emerging CoV.
has issue date	2020-03-07(xsd:dateTime)
bibo:doi	10.1101/2020.03.05.979260
bibo:pmid	32511345
has license	medrxiv
sha1sum (hex)	4b842d24ee59ce7b92acffda8b8d3d46e98fd223
schema:url	https://doi.org/10.1101/2020.03.05.979260
resource representing a document's title	LY6E impairs coronavirus fusion and confers immune control of viral disease
has PubMed identifier	32511345
schema:publication	bioRxiv
resource representing a document's body	covid:4b842d24ee59ce7b92acffda8b8d3d46e98fd223#body_text
is schema:about of	named entity 'Zoonotic' named entity 'Response' named entity 'regulated' named entity 'antiviral' named entity 'HCoV-229E' named entity 'human lung' named entity 'mice' named entity 'viral RNA' named entity 'HIV-1' named entity 'neutrophils' named entity 'MHV' named entity 'mice' named entity 'antiviral' named entity 'transfected' named entity 'Antiviral' named entity 'mice' named entity 'wild-type' named entity 'LY6E' named entity 'syncytia' named entity 'HCoV-229E' named entity 'PBS' named entity 'spleen' named entity 'ThermoScientific' named entity 'liver damage' named entity 'GPI-anchored' named entity '4a-c' named entity 'cDNA' named entity 'luciferase' named entity 'supernatant' named entity 'receptor' named entity 'locus' named entity 'protein' named entity 'cell-cell' named entity 'MHV' named entity 'histopathology' named entity 'mycoplasma' named entity 'macrophages' named entity 'GFP' named entity 'spleen' named entity 'viruses' named entity 'Assay' named entity 'orthologues' named entity 'Ly6e' named entity 'LY6E' named entity 'species barrier' named entity 'LY6E' named entity 'restriction factor' named entity 'protein' named entity 'Pseudotyping' named entity 'ectopically expressed' named entity 'MERS-CoV' named entity 'Molecular Devices' named entity 'flow cytometry' named entity 'mice' named entity 'ectopically expressed' named entity 'MHV' named entity 'penicillin' named entity 'liver inflammation' named entity 'MHV'

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