About: Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1

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About: Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1
Creator	Balmer, Yves Engelhard, Johanna Gutscher, Marcus Preuss, Marc Schwertassek, Ulla Weingarten, Lars Winkler, Monique Dick, Tobias
source	PMC
abstract	The thiol-disulfide oxidoreductase thioredoxin-1 (Trx1) is known to be secreted by leukocytes and to exhibit cytokine-like properties. Extracellular effects of Trx1 require a functional active site, suggesting a redox-based mechanism of action. However, specific cell surface proteins and pathways coupling extracellular Trx1 redox activity to cellular responses have not been identified so far. Using a mechanism-based kinetic trapping technique to identify disulfide exchange interactions on the intact surface of living lymphocytes, we found that Trx1 catalytically interacts with a single principal target protein. This target protein was identified as the tumor necrosis factor receptor superfamily member 8 (TNFRSF8/CD30). We demonstrate that the redox interaction is highly specific for both Trx1 and CD30 and that the redox state of CD30 determines its ability to engage the cognate ligand and transduce signals. Furthermore, we confirm that Trx1 affects CD30-dependent changes in lymphocyte effector function. Thus, we conclude that receptor–ligand signaling interactions can be selectively regulated by an extracellular redox catalyst.
has issue date	2007-07-11(xsd:dateTime)
bibo:doi	10.1038/sj.emboj.7601746
bibo:pmid	17557078
has license	cc-by-nc-nd
sha1sum (hex)	4b938c2f60ce863541ac9ca19fe0a98cd9a8730e
schema:url	https://doi.org/10.1038/sj.emboj.7601746
resource representing a document's title	Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1
has PubMed Central identifier	PMC1914094
has PubMed identifier	17557078
schema:publication	EMBO J
resource representing a document's body	covid:4b938c2f60ce863541ac9ca19fe0a98cd9a8730e#body_text
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