About: Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis

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About: Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis
Creator	Bahtiyar, Mert-Ozan Bhandari, Vineet Funai, Edmund Magloire, Lissa Paidas, Michael Zhao, Guomao Buhimschi, Catalin Buhimschi, Irina Copel, Joshua Hamar, Benjamin Lockwood, Charles Norwitz, Errol Pettker, Christian Sfakianaki, Anna Weiner, Carl
Source	Medline; PMC
abstract	BACKGROUND: Proteomic analysis of amniotic fluid shows the presence of biomarkers characteristic of intrauterine inflammation. We sought to validate prospectively the clinical utility of one such proteomic profile, the Mass Restricted (MR) score. METHODS AND FINDINGS: We enrolled 169 consecutive women with singleton pregnancies admitted with preterm labor or preterm premature rupture of membranes. All women had a clinically indicated amniocentesis to rule out intra-amniotic infection. A proteomic fingerprint (MR score) was generated from fresh samples of amniotic fluid using surface-enhanced laser desorption ionization (SELDI) mass spectrometry. Presence or absence of the biomarkers of the MR score was interpreted in relationship to the amniocentesis-to-delivery interval, placental inflammation, and early-onset neonatal sepsis for all neonates admitted to the Newborn Special Care Unit (n = 104). Women with “severe” amniotic fluid inflammation (MR score of 3 or 4) had shorter amniocentesis-to-delivery intervals than women with “no” (MR score of 0) inflammation or even “minimal” (MR score of 1 or 2) inflammation (median [range] MR 3–4: 0.4 d [0.0–49.6 d] versus MR 1–2: 3.8 d [0.0–151.2 d] versus MR 0: 17.0 d [0.1–94.3 d], p < 0.001). Nonetheless, a “minimal” degree of inflammation was also associated with preterm birth regardless of membrane status. There was a significant association between the MR score and severity of histological chorioamnionitis (r = 0.599, p < 0.001). Furthermore, neonatal hematological indices and early-onset sepsis significantly correlated with the MR score even after adjusting for gestational age at birth (OR for MR 3–4: 3.3 [95% CI, 1.1 to 9.2], p = 0.03). When compared with other laboratory tests routinely used to diagnose amniotic fluid inflammation and infection, the MR score had the highest accuracy to detect inflammation (white blood cell count > 100 cells/mm(3)), whereas the combination of Gram stain and MR score was best for rapid prediction of intra-amniotic infection (positive amniotic fluid culture). CONCLUSIONS: High MR scores are associated with preterm delivery, histological chorioamnionitis, and early-onset neonatal sepsis. In this study, proteomic analysis of amniotic fluid was shown to be the most accurate test for diagnosis of intra-amniotic inflammation, whereas addition of the MR score to the Gram stain provides the best combination of tests to rapidly predict infection.
has issue date	2007-01-16(xsd:dateTime)
bibo:doi	10.1371/journal.pmed.0040018
bibo:pmid	17227133
has license	cc-by
sha1sum (hex)	4b9911544622c1028499e1db9cf9fb783c2ed863
schema:url	https://doi.org/10.1371/journal.pmed.0040018
resource representing a document's title	Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis
has PubMed Central identifier	PMC1769412
has PubMed identifier	17227133
schema:publication	PLoS Med
resource representing a document's body	covid:4b9911544622c1028499e1db9cf9fb783c2ed863#body_text
is schema:about of	named entity 'TO DETECT' named entity 'PROTEOMIC PROFILING' named entity 'NEONATAL SEPSIS' named entity 'INFLAMMATION' named entity 'AMNIOTIC FLUID' named entity 'INFECTION' named entity 'IL-6' named entity 'calgranulin' named entity 'inflammation' named entity 'laboratory tests' named entity 'glucose' named entity 'microbes' named entity 'desorption' named entity 'amniotic fluid' named entity 'sepsis' named entity 'premature labor' named entity 'protein chip' named entity 'IL-6' named entity 'Amniotic Fluid' named entity 'Infection' named entity 'Neonatal Sepsis' named entity 'uterine contractions' named entity 'incubation time' named entity 'chorioamnionitis' named entity 'proteomic' named entity 'IL-6' named entity 'amniocentesis' named entity 'inflammation' named entity 'inflammatory response' named entity 'inflammation' named entity 'calgranulin' named entity 'proteomic' named entity 'mg/dl' named entity 'decidua' named entity 'infection' named entity 'inflammation' named entity 'proteomic' named entity 'umbilical cord' named entity 'defensin' named entity 'risk factor' named entity 'calgranulin' named entity 'inflammation' named entity 'inflammation' named entity 'proteomic' named entity 'interleukin-6' named entity 'MMP-8' named entity 'infection' named entity 'MMP-8' named entity 'p-value' named entity 'amniocentesis' named entity 'microbial culture' named entity 'Yale-New Haven Hospital' named entity 'antenatal' named entity 'inflammation' named entity 'ANC' named entity 'pregnancy' named entity 'ANOVA' named entity 'iatrogenic' named entity 'bioactive' named entity 'hypoperfusion' named entity 'neutrophil' named entity 'PPROM' named entity 'morbidity' named entity 'neonate' named entity 'protein' named entity 'placenta' named entity 'MMP-8'

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