About: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model
Creator	Wang, Chen Dai, Huaping Xiao, Fei Jia, Chune Li, Yanming Luo, Sa Xu, Xuefeng
source	PMC
abstract	BACKGROUND: Blood purification is an emerging approach to dampening the cytokine storm. This study aims to assess the efficacy of HA330 resin-directed hemoadsorption (HA) on endotoxin-induced porcine acute respiratory distress syndrome (ARDS) model. METHODS: Twenty-four Chinese domestic pigs were allocated into saline group receiving intravenous infusion of saline (N = 6) and endotoxin group receiving intravenous infusion of LPS (N = 18). When ALI model was initially diagnosed, six pigs in the LPS and saline group were killed for BALF and histopathological analysis. The remaining 12 pigs in LPS group received 3-h HA (N = 6) or HA-sham (N = 6) treatment, respectively. Following another 5-h observation, animals were killed. Variables on hemodynamics, blood gases and lung mechanics were recorded at a series of time points. Differentially expressed cytokines and proteins were determined by ELISA and proteomics. RESULTS: HA treatment significantly improved injured oxygenation induced by LPS. HA also partially improved the barrier permeability and reduced lung edema and inflammation/injury induced by LPS infusion. Proteomic analysis showed the differentially expressed proteins between HA- and HA-sham-treated groups mostly belonged to the categories of acute inflammation/immune response, and proteolysis. CONCLUSIONS: Hemoadsorption improved ARDS possibly by blunting the cytokine storm and by restoring homeostasis of the disordered proteome milieu in the exudative phase. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13613-017-0287-0) contains supplementary material, which is available to authorized users.
has issue date	2017-08-14(xsd:dateTime)
bibo:doi	10.1186/s13613-017-0287-0
bibo:pmid	28808944
has license	cc-by
sha1sum (hex)	4bae3f6031a50a23b169db5adf9e5db5d325e05d
schema:url	https://doi.org/10.1186/s13613-017-0287-0
resource representing a document's title	Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model
has PubMed Central identifier	PMC5555961
has PubMed identifier	28808944
schema:publication	Ann Intensive Care
resource representing a document's body	covid:4bae3f6031a50a23b169db5adf9e5db5d325e05d#body_text
is schema:about of	named entity 'This' named entity 'APPROACH' named entity 'aims' named entity 'cytokine storm' named entity 'resin' named entity 'porcine' named entity 'IL-1 family' named entity 'LPS' named entity 'saline' named entity 'alveolar' named entity 'experimental research' named entity 'milliliter' named entity 'BALF' named entity 'matrix metalloproteinases' named entity 'surfactant' named entity 'oleic acid' named entity 'lung edema' named entity 'ARDS' named entity 'IL-1Ra' named entity 'saline' named entity 'over-expressed' named entity 'infusion' named entity 'BALF' named entity 'TNF-α' named entity 'ELISA assay' named entity 'SVR' named entity 'molecular function' named entity 'alveolar' named entity 'BALF' named entity 'alveolar' named entity 'ARDS' named entity 'ITIH4' named entity 'ARDS' named entity 'ITIH4' named entity 'homogenate' named entity 'LPS' named entity 'plasma' named entity 'sepsis' named entity 'exudative' named entity 'infusion' named entity 'H2B' named entity 'mass spectrometric analysis' named entity 'resin' named entity 'LPS' named entity 'histologic evaluation' named entity 'homogenates' named entity 'ARDS' named entity 'inflammatory cytokines' named entity 'ARDS' named entity 'sham therapy' named entity 'BALF' named entity 'IL-6' named entity 'small sample' named entity 'homogenate' named entity 'animal models' named entity '5.6' named entity 'ARDS' named entity '13.0' named entity 'IL-17A' named entity 'Kruskal-Wallis test' named entity 'LPS' named entity 'saline' named entity 'BALF' named entity 'resin' named entity 'protein' named entity 'MAP' named entity 'PVPI' named entity 'oxygen' named entity 'sepsis' named entity 'ARDS' named entity 'capillary' named entity 'alveolar' named entity 'PVR' named entity 'SPSS' named entity 'MMP8'

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