About: Presence of factor VIII-related antigen in blood platelets of patients with Von Willebrand's disease

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About: Presence of factor VIII-related antigen in blood platelets of patients with Von Willebrand's disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Presence of factor VIII-related antigen in blood platelets of patients with Von Willebrand's disease
Creator	Alexander, D Pocock, D Floyd, J Reeve, P Duesberg, W Joklik, M Mishra, N Ryan, W Stone, R Watkins, H
Source	PMC
abstract	VON WILLEBRAND'S disease (VWD) is an autosomally inherited disorder characterised by low factor VIII activity (antihaemophilic factor, AHF), prolonged bleeding time, reduced retention of platelets in a glass bead column and abnormal distocetin-induced platelet aggregation. The prolonged bleeding time in VWD has been attributed to the absence of a plasma factor, the von Willebrand factor (VWF), as shown by a correction of the bleeding time after infusion of normal and haemophilic plasmas(1). Addition of purified factor VIII in vitro specifically corrects the abnormal platelet retention and ristocetin aggregation in VWD(2–5), whereas transfusion of similar material into dogs with VWD also corrects the prolonged bleeding time (B.N.B., W. J. Dodds, J. A. van Mourik, J.J.S and W. P. Webster, unpublished). This led to the suggestion that factor VIII is closely related if not identical to VWF, although dissociation of factor VIII procoagulant activity from factor VIII-related antigen (F VIII-RA) is observed in certain conditions(6,7). The plasma concentration of F VIII-RA is usually reduced in VWD suggesting a reduced synthesis of factor VIII (VWF)(8). In contrast to this we now report the presence of normal concentrations of F VIII-RA in platelets of patients with VWD. This F VIII-RA supported aggregation induced by ristocetin in a washed platelet system(9), a property of factor VIII which has been attributed to VWF activity.
has issue date	1975-01-01(xsd:dateTime)
bibo:doi	10.1038/257510a0
bibo:pmid	1080838
has license	no-cc
sha1sum (hex)	4bbcf37c8508b765cb8b2e2bc848bd592298dc91
schema:url	https://doi.org/10.1038/257510a0
resource representing a document's title	Presence of factor VIII-related antigen in blood platelets of patients with Von Willebrand's disease
has PubMed Central identifier	PMC7086501
has PubMed identifier	1080838
schema:publication	Nature
resource representing a document's body	covid:4bbcf37c8508b765cb8b2e2bc848bd592298dc91#body_text
is schema:about of	named entity 'RNA' named entity 'liberates' named entity 'disease' named entity 'FIG' covid:arg/4bbcf37c8508b765cb8b2e2bc848bd592298dc91 named entity 'viral' named entity '70S' named entity '70S' named entity 'haemostatic' named entity 'VIII' named entity 'plasma' named entity 'HEV' named entity 'RNA' named entity 'viral RNA' named entity 'antigen' named entity 'factor VIII' named entity 'VIII' named entity 'supernatant' named entity 'plasma' named entity 'benzamidine' named entity 'Platelet rich plasma' named entity 'megakaryocytic' named entity 'haemostatic' named entity 'platelet aggregation' named entity 'factor VIII' named entity 'factor VIII' named entity 'factor VIII' named entity 'fluorescein isothiocyanate' named entity 'platelets' named entity 'VIn' named entity 'platelets' named entity 'platelets' named entity 'haemostatic' named entity 'incubation' named entity 'factor VIII' named entity 'platelets' named entity 'platelets' named entity 'plasma' named entity 'VIII' named entity 'haemostasis' named entity 'lysates' named entity 'factor VIII' named entity 'platelets' named entity 'VWF' named entity 'extracellular' named entity 'molecule' named entity 'serum' named entity 'lysed' named entity 'immunoelectrophoresis' named entity 'thrombin' named entity 'plasma' named entity 'immunofluorescent' named entity 'leukocytes' named entity 'VWD' named entity 'caproic acid' named entity 'platelets' named entity 'platelets' named entity 'factor VIII' named entity 'protein content' named entity 'fluorescence microscope' named entity 'platelets' named entity 'platelets' named entity 'platelets' named entity 'VWD' named entity 'platelets' named entity 'factor VIII' named entity 'VWF' named entity 'infusion' named entity 'VWF' named entity 'tissue factor' named entity 'antisera' named entity 'haemostasis'

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