About: Concurrent porcine circovirus type 2a (PCV2a) or PCV2b infection increases the rate of amino acid mutations of porcine reproductive and respiratory syndrome virus (PRRSV) during serial passages in pigs

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About: Concurrent porcine circovirus type 2a (PCV2a) or PCV2b infection increases the rate of amino acid mutations of porcine reproductive and respiratory syndrome virus (PRRSV) during serial passages in pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Concurrent porcine circovirus type 2a (PCV2a) or PCV2b infection increases the rate of amino acid mutations of porcine reproductive and respiratory syndrome virus (PRRSV) during serial passages in pigs
Creator	Opriessnig, Tanja Xiao, Chao-Ting Gerber, Priscilla Meng, Xiang-Jin Yin, Shuang-Hui Halbur, Patrick Beach, Nathan
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) has a high degree of genetic and antigenic variability. The purpose of this study was to determine if porcine circovirus type 2 (PCV2) infection increases genetic variability of PRRSV during serial passages in pigs and to determine if there is a difference in the PRRSV mutation rate between pigs concurrently infected with PCV2a or PCV2b. After 8 consecutive passages of PRRSV alone (group 1), PRRSV with PCV2a (group 2), or PCV2b (group 3) in pigs, the sequences of PRRSV structural genes for open reading frame (ORF) 5, ORF6, ORF7 and the partial non-structural protein gene (Nsp) 2 were determined. The total number of identified amino acid mutations in ORF5, ORF6, ORF7 and Nsp2 sequences was 30 for PRRSV infection only, 63 for PRRSV/PCV2a concurrent infection, and 77 for PRRSV/PCV2b concurrent infection when compared with the original VR2385 virus used to infect the passage 1 pigs. Compared to what occurred in pigs infected with PRRSV only, the mutation rates in ORF5 and ORF6 were significantly higher for concurrent PRRSV/PCV2b infected pigs. The PRRSV/PCV2a pigs had a significantly higher mutation rate in ORF7. The results from this study indicated that, besides ORF5 and Nsp2, the PRRSV structural genes ORF6 and ORF7 were shown to mutate at various degrees when the PRRSV was passaged over time in vivo. Furthermore, a significantly higher mutation rate of PRRSV was observed when pigs were co-infected with PCV2 highlighting the importance of concurrent infections on PRRSV evolution and control.
has issue date	2013-12-26(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2013.09.007
bibo:pmid	24036229
has license	els-covid
sha1sum (hex)	4bcb2a658a05235e339239286458a3bb784d62c6
schema:url	https://doi.org/10.1016/j.virusres.2013.09.007
resource representing a document's title	Concurrent porcine circovirus type 2a (PCV2a) or PCV2b infection increases the rate of amino acid mutations of porcine reproductive and respiratory syndrome virus (PRRSV) during serial passages in pigs
has PubMed Central identifier	PMC7126594
has PubMed identifier	24036229
schema:publication	Virus Research
resource representing a document's body	covid:4bcb2a658a05235e339239286458a3bb784d62c6#body_text
is schema:about of	named entity 'PIGS' named entity 'mutation rate' named entity 'pigs' named entity 'determine' named entity 'pigs' named entity 'protein' named entity 'AMINO ACID' named entity 'DIFFERENCE' named entity 'SERIAL' named entity 'CONCURRENT' named entity 'INFECTION' named entity 'TO INFECT' named entity 'ORF6' named entity 'WHAT' named entity 'MUTATION RATE' named entity 'OCCURRED' named entity 'SERIAL' named entity 'PIGS' named entity 'EVOLUTION' named entity 'INFECTION ONLY' named entity 'NON-' covid:arg/4bcb2a658a05235e339239286458a3bb784d62c6 named entity 'STRUCTURAL GENES' named entity 'CONCURRENT' named entity 'OBSERVED' named entity 'DETERMINE' named entity 'VIRUS' named entity 'NUMBER OF' named entity 'TOTAL NUMBER' named entity 'GENETIC' named entity 'INCREASES' named entity 'PORCINE CIRCOVIRUS TYPE 2A' named entity 'VARIOUS' named entity 'NSP2' named entity 'MUTATE' named entity 'INDICATED' named entity 'INFECTIONS' named entity 'GENETIC VARIABILITY' named entity 'MUTATIONS' named entity 'INCREASES' named entity 'MUTATIONS' named entity 'HIGHLIGHTING' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'PASSAGE' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'INFECTED' named entity 'RESULTS' named entity 'IS A' named entity 'AMINO ACID' named entity 'COMPARED' named entity 'STRUCTURAL PROTEIN GENE' named entity 'PARTIAL' named entity 'PCV2B' named entity 'RATE' named entity 'VARIABILITY' named entity 'DEGREE' named entity 'PURPOSE' named entity 'PCV2B' named entity 'CONTROL' named entity 'INFECTION' named entity 'SEQUENCES' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'TIME' named entity 'DEGREES' named entity 'IDENTIFIED' named entity 'STUDY' named entity 'IN VIVO' named entity 'USED' named entity 'OPEN READING FRAME' named entity 'CONSECUTIVE' named entity 'ORF5' named entity 'PCV2A' named entity 'ORIGINAL' named entity 'HIGH' named entity 'mutations'

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