About: A Novel Bacterium-Like Particle-Based Vaccine Displaying the SUDV Glycoprotein Induces Potent Humoral and Cellular Immune Responses in Mice

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About: A Novel Bacterium-Like Particle-Based Vaccine Displaying the SUDV Glycoprotein Induces Potent Humoral and Cellular Immune Responses in Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Novel Bacterium-Like Particle-Based Vaccine Displaying the SUDV Glycoprotein Induces Potent Humoral and Cellular Immune Responses in Mice
Creator	Xia, Xianzhu Yang, Songtao He, Hongbin Wang, Jianzhong Chi, Hang Feng, Na Gao, Yuwei Wang, Hualei Zhao, Yongkun Zhang, Shengnan Jin, Hongli Li, Entao Yan, Feihu Cao, Zengguo Jiao, Cuicui Li, Wujian Shi, Zhikang Xu, Shengnan
Source	Medline; PMC
abstract	Sudan virus (SUDV) causes severe lethal hemorrhagic fever in humans and nonhuman primates. The most effective and economical way to protect against Sudan ebolavirus disease is prophylactic vaccination. However, there are no licensed vaccines to prevent SUDV infections. In this study, a bacterium-like particle (BLP)-based vaccine displaying the extracellular domain of the SUDV glycoprotein (eGP) was developed based on a gram-positive enhancer matrix-protein anchor (GEM-PA) surface display system. Expression of the recombinant GEM-displayed eGP (eGP-PA-GEM) was verified by Western blotting and immunofluorescence assays. The SUDV BLPs (SBLPs), which were mixed with Montanide ISA 201VG plus Poly (I:C) combined adjuvant, could induce high SUDV GP-specific IgG titers of up to 1:40,960 and robust virus-neutralizing antibody titers reached 1:460. The SBLP also elicited T-helper 1 (Th1) and T-helper 2 (Th2) cell-mediated immunity. These data indicate that the SBLP subunit vaccine has the potential to be developed into a promising candidate vaccine against SUDV infections.
has issue date	2019-12-11(xsd:dateTime)
bibo:doi	10.3390/v11121149
bibo:pmid	31835785
has license	cc-by
sha1sum (hex)	4bcdac71c12d45032dfb8c6753e7d94643a11283
schema:url	https://doi.org/10.3390/v11121149
resource representing a document's title	A Novel Bacterium-Like Particle-Based Vaccine Displaying the SUDV Glycoprotein Induces Potent Humoral and Cellular Immune Responses in Mice
has PubMed Central identifier	PMC6950126
has PubMed identifier	31835785
schema:publication	Viruses
resource representing a document's body	covid:4bcdac71c12d45032dfb8c6753e7d94643a11283#body_text
is schema:about of	named entity 'immunofluorescence assays' named entity 'prevent' named entity 'EVD' named entity 'outbreak' named entity 'vaccine' named entity 'surface' named entity 'The' named entity 'EBOV' named entity 'Immune' covid:arg/4bcdac71c12d45032dfb8c6753e7d94643a11283 named entity 'cases' named entity 'study' named entity 'These' named entity 'IgG' named entity 'EVD' named entity 'infections' named entity 'Bundibugyo' named entity 'Th2' named entity '1998' named entity 'antibody' named entity 'receiving' named entity 'vaccination' named entity 'adjuvant' named entity 'Taï Forest' named entity 'T-helper' named entity 'reached' named entity 'subunit vaccine' named entity '2018' named entity 'enhancer' named entity 'Sudan ebolavirus' named entity 'subunit vaccine' named entity 'ebolaviruses' named entity 'recombinant' named entity 'SUDV' named entity 'EVD' named entity 'SUDV' named entity 'Western blotting' named entity 'SUDV' named entity 'vaccine' named entity 'Cellular Immune Responses' named entity 'SUDV' named entity 'IgG' named entity 'virus-like particle' named entity 'IL-4' named entity 'neutralizing antibody' named entity 'germinal center' named entity 'TNF-α' named entity 'protein expression' named entity 'Th2 response' named entity 'SUDV' named entity 'IgG2a' named entity 'morbidity' named entity 'Th2' named entity 'La Jolla' named entity 'Stockholm' named entity 'monoclonal antibody' named entity 'IgG' named entity 'antigens' named entity 'SUDV' named entity 'one-way ANOVA' named entity 'TNF-α' named entity 'antibody' named entity 'IL-10' named entity 'T-helper'

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