About: TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase

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About: TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase
Creator	Chen, Yu Li, Yan Wang, Huijuan Zhang, Mingshun Xu, Ying Chen, Xichen Gan, Tingting Hu, Fan Yang, Yonglin Zhou, Jiawei Li, Zhou Laskay, Tamás Prakash, Hridayesh Travassos, Leonardo
Source	Medline; PMC
abstract	Acute lung injury (ALI) is the leading cause of morbidity and mortality in critically ill patients. Neutrophil extracellular traps (NETs) have been well documented in the ALI model of bacterial infection. In the present study, we demonstrated that poly I:C could induce pulmonary NETs. Upon poly I:C intratracheal inoculation, neutrophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly increased. Furthermore, the inflammatory cytokines IL-1β, IL-6, and TNF-α in the lung were also significantly elevated. Neutrophil depletion abolished NETs and decreased both neutrophil infiltration and IL-1β in the lung. As expected, DNase I, an inhibitor of MPO and NADPH, decreased pulmonary inflammation and NETs. Blocking of the poly I:C receptor TLR3 reduced lung inflammation and NETs. The MAPK kinase inhibitor p38 diminished the formation of NETs and restored the expression of the tight junction protein claudin-5 in the mouse lung when challenged with poly I:C. In summary, poly I:C induced the formation of pulmonary NETs and ALI, which may be associated with the activation of p38 MAPK and the decreased expression of claudin-5.
has issue date	2018-12-21(xsd:dateTime)
bibo:doi	10.3389/fmicb.2018.03174
bibo:pmid	30622526
has license	cc-by
sha1sum (hex)	4c30f4001fb0068ba0b1444ea16b4d9cbe672996
schema:url	https://doi.org/10.3389/fmicb.2018.03174
resource representing a document's title	TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase
has PubMed Central identifier	PMC6308186
has PubMed identifier	30622526
schema:publication	Front Microbiol
resource representing a document's body	covid:4c30f4001fb0068ba0b1444ea16b4d9cbe672996#body_text
is schema:about of	named entity 'P38 MAP KINASE' named entity 'critically ill' named entity 'NETs' named entity 'p38 MAPK' named entity 'TLR3' named entity 'LUNG INFLAMMATION' named entity 'MOUSE LUNG' named entity 'PRESENT' named entity 'TIGHT JUNCTION' named entity 'IL-1' named entity 'CLAUDIN-5' named entity 'CYTOKINES' named entity 'EXTRACELLULAR TRAPS' named entity 'ACTIVATION OF P38 MAPK' named entity 'DEPLETION' named entity 'HAVE' named entity 'PROTEIN ' named entity 'PATIENTS' named entity 'MPO' named entity 'DOCUMENTED' named entity 'BLOCKING' named entity 'PULMONARY' named entity 'BACTERIAL INFECTION' named entity 'ACUTE LUNG INJURY' named entity 'MORBIDITY AND MORTALITY' named entity 'DNASE I' named entity 'DECREASED EXPRESSION' named entity 'REDUCED' named entity 'INDUCED' named entity 'SUMMARY' named entity 'PULMONARY INFLAMMATION' named entity 'LUNG' named entity 'DEMONSTRATED' named entity 'ACUTE LUNG INJURY' named entity 'AS EXPECTED' named entity 'MODEL OF' named entity 'KINASE INHIBITOR' named entity 'STUDY' named entity 'LEADING' named entity 'INDUCE' named entity 'POLY I' named entity 'EXTRACELLULAR TRAPS' named entity 'INDUCED' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'TNF' named entity 'IL-6' named entity 'NEUTROPHIL INFILTRATION' named entity 'RECEPTOR' named entity 'TLR3' named entity 'INTRATRACHEAL' named entity 'CRITICALLY ILL' named entity 'NADPH' named entity 'CAUSE' named entity 'INOCULATION' named entity 'INHIBITOR' named entity 'NEUTROPHIL' named entity 'TLR3' named entity 'REGULATED' named entity 'MAPK KINASE' named entity 'EXPRESSION' named entity 'P38' named entity 'NEUTROPHIL' named entity 'INFLAMMATORY' named entity 'DECREASED' named entity 'FORMATION' named entity 'ABOLISHED' named entity 'INCREASED' named entity 'DIMINISHED'

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