About: Environmental Contamination and Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea

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About: Environmental Contamination and Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Environmental Contamination and Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea
Creator	Park, Su-Jin Lee, Jacob Song, Min-Suk Choi, Won-Suk Kim, Eun-Ha Si, Young-Jae Min, Jinsoo Choi, Young Jeong, Hye Kim, Se Kim, Young-Il Kwon, Hyeok-Il Yeon Heo, Jung Baek, Yun Bin, Seo Lee, In-Won
Source	Medline; PMC
abstract	Background. Although Middle East Respiratory Syndrome coronavirus (MERS-CoV) is characterized by a risk of nosocomial transmission, the detailed mode of transmission and period of virus shedding from infected patients are poorly understood. The aims of this study were to investigate the potential role of environmental contamination by MERS-CoV in healthcare settings and to define the period of viable virus shedding from MERS patients. Methods. We investigated environmental contamination from 4 patients in MERS-CoV units of 2 hospitals. MERS-CoV was detected by reverse transcription polymerase chain reaction (PCR) and viable virus was isolated by cultures. Results. Many environmental surfaces of MERS patient rooms, including points frequently touched by patients or healthcare workers, were contaminated by MERS-CoV. Viral RNA was detected up to five days from environmental surfaces following the last positive PCR from patients’ respiratory specimens. MERS-CoV RNA was detected in samples from anterooms, medical devices, and air-ventilating equipment. In addition, MERS-CoV was isolated from environmental objects such as bed sheets, bedrails, IV fluid hangers, and X-ray devices. During the late clinical phase of MERS, viable virus could be isolated in 3 of the 4 enrolled patients on day 18 to day 25 after symptom onset. Conclusions. Most of touchable surfaces in MERS units were contaminated by patients and health care workers and the viable virus could shed through respiratory secretion from clinically fully recovered patients. These results emphasize the need for strict environmental surface hygiene practices, and sufficient isolation period based on laboratory results rather than solely on clinical symptoms.
has issue date	2016-03-15(xsd:dateTime)
bibo:doi	10.1093/cid/civ1020
bibo:pmid	26679623
has license	no-cc
sha1sum (hex)	4c9247f45d1753097c240b772fff1d0fd97a12a7
schema:url	https://doi.org/10.1093/cid/civ1020
resource representing a document's title	Environmental Contamination and Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea
has PubMed Central identifier	PMC7108026
has PubMed identifier	26679623
schema:publication	Clin Infect Dis
resource representing a document's body	covid:4c9247f45d1753097c240b772fff1d0fd97a12a7#body_text
is schema:about of	named entity 'ROLE' named entity 'AIMS' named entity 'HEALTHCARE' named entity 'POORLY' named entity 'ENVIRONMENTAL CONTAMINATION' named entity 'SOUTH KOREA' named entity 'OUTBREAK' named entity 'MERS-COV' named entity 'STUDY' named entity 'ENVIRONMENTAL CONTAMINATION' named entity 'CLINICAL' named entity 'INFECTIOUS DISEASES' named entity 'VIRUS SHEDDING' named entity 'UNDERSTOOD' named entity 'NOSOCOMIAL TRANSMISSION' named entity 'POTENTIAL' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'PATIENTS' named entity 'RISK OF' named entity 'BACKGROUND' named entity 'MODE OF TRANSMISSION' named entity 'SETTINGS' named entity 'DETAILED' named entity 'PERIOD' named entity 'INFECTED' named entity 'CHARACTERIZED' named entity 'VIRAL SHEDDING' named entity 'MERS' named entity 'PATIENTS' named entity 'MERS' named entity 'VIABLE' named entity 'TO INVESTIGATE' named entity 'mode' named entity 'patients' named entity 'detailed' named entity 'transmission' named entity 'nosocomial' named entity 'MERS-CoV' named entity 'South Korea' named entity 'MERS' named entity 'isolation room' named entity 'RT-PCR' named entity 'clinical symptoms' named entity 'MERS-CoV' named entity 'RNA' named entity 'transport medium' named entity 'MERS-CoV' named entity 'Streptomycin' named entity 'Huh7' named entity 'clinical phase' named entity 'RNA' named entity 'healthcare workers' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'viral culture' named entity 'MERS-CoV' named entity 'X-ray' named entity 'MERS' named entity 'FCS' named entity 'Biosafety Level 3' named entity 'North America' named entity 'MERS-CoV' named entity 'severe pneumonia' named entity 'RT-PCR' named entity 'aerosol' named entity 'IV fluid'

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