About: Map of SARS-CoV-2 spike epitopes not shielded by glycans

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Map of SARS-CoV-2 spike epitopes not shielded by glycans
Creator	Hummer, Gerhard Blanc, Florian Covino, Roberto Gecht, Michael Sikora, Mateusz Von Bülow, Sören
Source	BioRxiv
abstract	The severity of the COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, calls for the urgent development of a vaccine. The primary immunological target is the SARS-CoV-2 spike (S) protein. S is exposed on the viral surface to mediate viral entry into the host cell. To identify possible antibody binding sites not shielded by glycans, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins. By mapping steric accessibility, structural rigidity, sequence conservation and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for vaccine development. We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics in epitope mapping.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1101/2020.07.03.186825
has license	biorxiv
sha1sum (hex)	4d140d2aa6eda07fffd1c04fe1ad3135c4561061
schema:url	https://doi.org/10.1101/2020.07.03.186825
resource representing a document's title	Map of SARS-CoV-2 spike epitopes not shielded by glycans
schema:publication	bioRxiv
resource representing a document's body	covid:4d140d2aa6eda07fffd1c04fe1ad3135c4561061#body_text
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