About: Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia

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About: Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia
Creator	Peiris, Malik Abu-Obeida, Ali Al-Doweriej, Ali Al-Hufofi, Ali Al-Romaihi, Ahmed Alkarar, Ali Babekr, Nasereldeen Bayoumi, Faisal El-Harby, Nadr Elfadil, Abdelhamid Gaafer, Albagir Hashim, Osman Hussien, Raed Kasem, Samy Qasim, Ibraheem Zaki, Ahmed Poon, Leo Chu, Daniel Al-Sahaf, Ali Perera, Ranawaka
source	Elsevier; Medline; PMC
abstract	Abstract Background Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerged coronavirus that is associated with a severe respiratory disease in humans in the Middle East. The epidemiological profiles of the MERS-CoV infections suggest zoonotic transmission from an animal reservoir to humans. Methods This study was designed to investigate animal herds associated with Middle East respiratory syndrome (MERS)-infected patients in Saudi Arabia, during the last three years (2014–2016). Nasal swabs and serum samples from 584 dromedary camels, 39 sheep, 51 goats, and 2 cattle were collected. Nasal samples from camels, sheep, goats, and cattle were examined by real-time reverse-transcription PCR (RT-PCR) to detect MERS-CoV RNA, and the Anti-MERS ELISA assay was performed to detect camel humeral immune response (IgG) to MERS-CoV S1 antigen infection. The complete genome sequencing of ten MERS-CoV camel isolates and phylogenetic analysis was performed. Results The data indicated that seventy-five dromedary camels were positive for MERS-CoV RNA; the virus was not detected in sheep, goats, and cattle. MERS-CoV RNA from infected camels was not detected beyond 2 weeks after the first positive result was detected in nasal swabs obtained from infected camels. Anti-MERS ELISA assays showed that 70.9% of camels related to human cases had antibodies to MERS-CoV. The full genome sequences of the ten MERS-CoV camel isolates were identical to their corresponding patients and were grouped together within the larger MERS-CoV sequences cluster for human and camel isolates reported form the Arabian Peninsula. Conclusions These findings indicate that camels are a significant reservoir for the maintenance of MERS-CoVs, and they are an important source of human infection with MERS.
has issue date	2018-06-30(xsd:dateTime)
bibo:doi	10.1016/j.jiph.2017.09.022
bibo:pmid	28993171
has license	els-covid
sha1sum (hex)	4d1e612e20a20982d6e1a7cd01bccef469cc549f
schema:url	https://doi.org/10.1016/j.jiph.2017.09.022
resource representing a document's title	Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia
has PubMed Central identifier	PMC7102853
has PubMed identifier	28993171
schema:publication	Journal of Infection and Public Health
resource representing a document's body	covid:4d1e612e20a20982d6e1a7cd01bccef469cc549f#body_text
is schema:about of	named entity 'MERS-COV' named entity 'infections' named entity 'camels' named entity 'isolates' named entity 'MERS-CoV' named entity 'infected' named entity 'SAUDI ARABIA' named entity 'SEQUENCES' named entity 'NOT DETECTED' named entity 'SERUM' named entity 'PERFORMED' named entity 'HUMERAL' named entity 'CAMELS' named entity 'SUGGEST' named entity 'NASAL' named entity 'NEWLY' named entity 'ASSOCIATED WITH' named entity 'GROUPED' named entity 'ARABIAN PENINSULA' named entity 'EXAMINED' named entity 'POSITIVE RESULT' named entity 'ZOONOTIC' named entity 'DROMEDARY' named entity 'EPIDEMIOLOGICAL' named entity 'BACKGROUND' named entity 'BEYOND' named entity 'SOURCE' named entity 'RESPIRATORY DISEASE' named entity 'IMMUNE RESPONSE' named entity 'GOATS' named entity 'HUMANS' named entity 'REVERSE-TRANSCRIPTION' named entity 'PATIENTS' named entity 'CAMEL' named entity 'COMPLETE GENOME SEQUENCING' named entity 'METHODS' named entity 'POSITIVE FOR' named entity 'IS A' named entity 'TRANSMISSION' named entity 'CLUSTER' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'INFECTIONS' named entity '2 WEEKS' named entity 'MIDDLE EAST' named entity 'IMPORTANT' named entity 'STUDY' named entity 'TO DETECT' named entity 'CORONAVIRUS' named entity 'YEARS' named entity 'IDENTICAL' named entity 'REAL-TIME' named entity 'MERS' named entity 'RELATED' named entity 'RNA' named entity 'RESERVOIR' named entity 'PCR' named entity 'CASES' named entity 'INDICATED' named entity 'HUMAN' named entity 'GENOME' named entity 'SAMPLES' named entity 'TO INVESTIGATE'

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