About: Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses
Creator	Chen, Lei Zhou, Tongqing Ofek, Gilad Sastry, Mallika Kong, Leopold Changela, Anita Kwon, Young Kwong, Peter Mclellan, Jason Nabel, Gary Boyington, Jeffrey Pancera, Marie Acharya, Priyamvada Kim, Albert Stuckey, Jonathan Hood, Chantelle Majeed, Shahzad
source	PMC
abstract	Structural biology provides a wealth of information about the three-dimensional organization and chemical makeup of proteins. An understanding of atomic-level structure offers enormous potential to design rationally proteins that stimulate specific immune responses. Yet current vaccine development efforts makes little use of structural information. At the Vaccine Research Center, a major goal is to apply structural techniques to vaccine design for challenging pathogens, that include human immunodeficiency virus type 1 (HIV-1) and other enveloped viruses such as influenza, Ebola, and respiratory syncytial viruses. Our three-part strategy involves 1.) the definition of the functional viral spike at the atomic level 2.) achieving a structural understanding of how neutralizing antibodies recognize the spike, and 3.) rational development of proteins that can elicit a specific antibody response. Overall, our strategy aims to incorporate information about viral spike-antibody interactions, to assimilate immunogenic feedback, and to leverage recent advances in immunofocusing and computational biology.
has issue date	2010-03-30(xsd:dateTime)
bibo:doi	10.1007/978-1-60761-512-5_39
has license	no-cc
sha1sum (hex)	4d6adcb52402016390c63d7cb4a9fef94495be48
schema:url	https://doi.org/10.1007/978-1-60761-512-5_39
resource representing a document's title	Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses
has PubMed Central identifier	PMC7176257
schema:publication	National Institute of Allergy and Infectious Diseases, NIH
resource representing a document's body	covid:4d6adcb52402016390c63d7cb4a9fef94495be48#body_text
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