About: Challenges in mucosal vaccination of cattle

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Challenges in mucosal vaccination of cattle
Creator	Hodgins, D Carrasco-Medina, L Mcbey, B Shewen, P
Source	Elsevier; Medline; PMC
abstract	Abstract Recognition of the mucosal portal of entry for many infectious diseases and of the relevance of mucosal immune response to protection has encouraged the development of vaccines administered by mucosal routes, principally oral and intranasal, for stimulation of intestinal and nasopharyngeal lymphoid tissues respectively. The oral route is problematic in cattle and other ruminants where antigen degradation in the rumen is likely, prior to transit to the intestine. On the other hand, rumination can be exploited for exposure of nasopharyngeal tissues during cudding if vaccine antigen is expressed by a fibrous feed like alfalfa. An increase in anti-leukotoxin (Lkt) IgA was demonstrated in nasal secretions of calves following feeding of alfalfa expressing a truncated Lkt50 from Mannheimia haemolytica, and there is evidence suggesting that such vaccination may protect against experimentally induced pneumonia. Intranasal vaccination is an alternative approach for use in pre-ruminating calves. Intranasal administration of ISCOMs carrying soluble antigens of M. haemolytica, including native Lkt, induced Lkt specific IgA in nasal secretions after vaccination at 4 and 6 weeks of age. Subcutaneous (s.c.) administration of the same vaccine induced Lkt specific IgG in both serum and nasal secretions, whereas s.c. administration of a commercial M. haemolytica vaccine did not. Regardless of the vaccination strategy employed it is difficult to assess the immunogenicity of mucosally administered vaccines because production of secreted antibodies tends to be transient, and they do not persist on the mucosal surface in the absence of ongoing antigenic stimulation. An additional challenge is demonstration of vaccine efficacy in response to experimental infection. Protection of the mucosally vaccinated animal will most probably result from recall response, which may not amplify sufficiently to counter the effects of experimental pulmonary delivery of a large bolus of virulent bacteria, even though the response would suffice over the more prolonged and gradual infection that occurs in natural induction of pneumonia.
has issue date	2009-03-15(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2008.10.297
bibo:pmid	19046777
has license	els-covid
sha1sum (hex)	4d77c1be3e298496537c5d106afeb77655b9ca13
schema:url	https://doi.org/10.1016/j.vetimm.2008.10.297
resource representing a document's title	Challenges in mucosal vaccination of cattle
has PubMed Central identifier	PMC7127216
has PubMed identifier	19046777
schema:publication	Veterinary Immunology and Immunopathology
resource representing a document's body	covid:4d77c1be3e298496537c5d106afeb77655b9ca13#body_text
is schema:about of	named entity 'CATTLE' named entity 'MUCOSAL VACCINATION' named entity 'CHALLENGES' named entity 'IgG1' named entity 'commensal' named entity 'Lkt' named entity 'vaccine' named entity 'titer' named entity 'correlation' named entity 'vaccine' named entity 'alfalfa' named entity 'bacterial toxin' named entity 'alfalfa' named entity 'viruses' named entity 'Intranasal' named entity 'antibodies' named entity 'pneumonia' named entity 'Lkt' named entity 'antigens' named entity 'mucosal immunity' named entity 'glycosylation' named entity 'Immunopathology' named entity 'intestine' named entity 'lymphoid tissues' named entity 'alfalfa' named entity 'antigen' named entity 'IgA' named entity 'CFU' named entity 'Vaccination' named entity 'transgenic' named entity 'Wyeth' named entity 'transgenic' named entity 'Ontario Ministry of Agriculture, Food and Rural Affairs' named entity 'blood cell' named entity 'supernatants' named entity 'Intranasal administration' named entity 'vesicles' named entity 'pneumonia' named entity 'DCs' named entity 'lymphoid tissues' named entity 'Peyer's patches' named entity 'adjuvants' named entity 'isotypic' named entity 'vertical bar' named entity 'maternal antibodies' named entity 'immunogenicity' named entity 'active immunity' named entity 'heifers' named entity 'antigens' named entity 'serum' named entity 'mice' named entity 'Elsevier' named entity 'nasopharyngeal' named entity 'interferon gamma' named entity 'enzootic pneumonia' named entity 'cattle' named entity 'immunogenicity' named entity 'antibodies' named entity 'necropsy' named entity 'N-linked' named entity 'alfalfa' named entity 'rumination' named entity 'vaccination' named entity 'pneumonic' named entity 'colostrum' named entity 'lung' named entity 'coronavirus' named entity 'Lkt' named entity 'antigen' named entity 'influenza viruses' named entity 'ELISpot' named entity 'rumen' named entity 'veal' named entity 'serum' named entity 'ciliated columnar epithelial cells' named entity 'vaccination' named entity 'alfalfa' named entity 'IFNg'

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