About: GSK3: A Kinase Balancing Promotion and Resolution of Inflammation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
Creator	Brand, Korbinian Diekmann, Mareike Hoffmeister, Leonie Huber, René
Source	Medline; PMC
abstract	GSK3 has been implicated for years in the regulation of inflammation and addressed in a plethora of scientific reports using a variety of experimental (disease) models and approaches. However, the specific role of GSK3 in the inflammatory process is still not fully understood and controversially discussed. Following a detailed overview of structure, function, and various regulatory levels, this review focusses on the immunoregulatory functions of GSK3, including the current knowledge obtained from animal models. Its impact on pro-inflammatory cytokine/chemokine profiles, bacterial/viral infections, and the modulation of associated pro-inflammatory transcriptional and signaling pathways is discussed. Moreover, GSK3 contributes to the resolution of inflammation on multiple levels, e.g., via the regulation of pro-resolving mediators, the clearance of apoptotic immune cells, and tissue repair processes. The influence of GSK3 on the development of different forms of stimulation tolerance is also addressed. Collectively, the role of GSK3 as a kinase balancing the initiation/perpetuation and the amelioration/resolution of inflammation is highlighted.
has issue date	2020-03-28(xsd:dateTime)
bibo:doi	10.3390/cells9040820
bibo:pmid	32231133
has license	cc-by
sha1sum (hex)	4d77f52bf4a8b03a87c88fe4973ffa205a1bddd0
schema:url	https://doi.org/10.3390/cells9040820
resource representing a document's title	GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
has PubMed Central identifier	PMC7226814
has PubMed identifier	32231133
schema:publication	Cells
resource representing a document's body	covid:4d77f52bf4a8b03a87c88fe4973ffa205a1bddd0#body_text
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