About: Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y

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About: Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y
Creator	Choi, Bong-Suk Choi, Han-Seok Kim, Sung-Jun Kumar, • Lee, Jeong Hyo, Kim Seung, Sapkota
Source	Medline; PMC
abstract	The present work was conducted to investigate the antioxidant activity and neuroprotective effects of Tripterygium regelii extract (TRE) on H(2)O(2)-induced apoptosis in human dopaminergic cells, SH-SY5Y. TRE possessed considerable amounts of phenolics (282.73 mg tannic acid equivalents/g of extract) and flavonoids (101.43 mg naringin equivalents/g of extract). IC(50) values for reducing power and DPPH radical scavenging activity were 52.51 and 47.83 μg, respectively. The H(2)O(2) scavenging capacity of TRE was found to be 57.68 μM × μg(−1) min(−1). By examining the effects of TRE on SH-SY5Y cells injured by H(2)O(2), we found that after incubation of cells with TRE prior to H(2)O(2) exposure, the H(2)O(2) induced cytotoxicity was significantly reversed and the apoptotic features such as change in cellular morphology, nuclear condensation and DNA fragmentation was inhibited. Moreover, TRE was very effective attenuating the disruption of mitochondrial membrane potential and apoptotic cell death induced by H(2)O(2). TRE extract effectively suppressed the up-regulation of Bax, Caspase-3 and -9, and down-regulation of Bcl-2. Moreover, TRE pretreatment evidently increased the tyrosine hydroxylase (TH) and brain-derived neurotrophic factor (BDNF) in SH-SY5Y cells. These findings demonstrate that TRE protects SH-SY5Y cells against H(2)O(2)-induced injury and antioxidant properties may account for its neuroprotective actions and suggest that TRE might potentially serve as an agent for prevention of neurodegenerative disease associated with oxidative stress.
has issue date	2010-05-14(xsd:dateTime)
bibo:doi	10.1007/s11064-010-0185-4
bibo:pmid	20467894
has license	no-cc
sha1sum (hex)	4d8c1c3a9883f12f8aaec7c909984bfbcdc0687c
schema:url	https://doi.org/10.1007/s11064-010-0185-4
resource representing a document's title	Antioxidant Activity and Protective Effects of Tripterygium regelii Extract on Hydrogen Peroxide-Induced Injury in Human Dopaminergic Cells, SH-SY5Y
has PubMed Central identifier	PMC7089404
has PubMed identifier	20467894
schema:publication	Neurochem Res
resource representing a document's body	covid:4d8c1c3a9883f12f8aaec7c909984bfbcdc0687c#body_text
is schema:about of	named entity 'INJURY' named entity 'INDUCED' named entity 'effectively' named entity 'injury' named entity 'induced' named entity 'induced' named entity 'induced' named entity 'down-regulation' named entity 'PHENOLICS' named entity 'LM 9' named entity 'DISRUPTION' named entity 'DOWN-REGULATION' named entity 'TRIPTERYGIUM REGELII' named entity 'RADICAL SCAVENGING ACTIVITY' named entity 'HUMAN' named entity 'SUPPRESSED' named entity 'CYTOTOXICITY' named entity 'TYROSINE HYDROXYLASE' named entity 'PRESENT' named entity 'ACCOUNT' named entity 'DOPAMINERGIC CELLS' named entity 'SERVE' named entity 'INJURED' named entity 'BRAIN-DERIVED NEUROTROPHIC FACTOR' named entity 'DNA FRAGMENTATION' named entity 'ANTIOXIDANT ACTIVITY' named entity '2 O' named entity 'EQUIVALENTS' named entity 'REVERSED' named entity 'APOPTOSIS' named entity 'AGENT' named entity 'HUMAN' named entity 'DOPAMINERGIC CELLS' named entity 'EFFECTS' named entity 'EXTRACT' named entity 'TANNIC ACID' named entity 'OXIDATIVE STRESS' named entity 'BCL-2' named entity 'H 2' named entity 'FLAVONOIDS' named entity 'BAX' named entity 'TRIPTERYGIUM REGELII' named entity 'HYDROGEN PEROXIDE' named entity 'SH-SY5Y' named entity 'AND BRAIN' named entity 'SCAVENGING' named entity 'AMOUNTS' named entity 'SUGGEST' named entity 'NUCLEAR CONDENSATION' named entity 'PREVENTION OF' named entity 'CHANGE IN' named entity 'MITOCHONDRIAL MEMBRANE POTENTIAL' named entity 'UP-REGULATION' named entity 'NEURODEGENERATIVE DISEASE' named entity 'VALUES' named entity 'PRETREATMENT' named entity 'POWER' named entity 'MIN' named entity 'THE UP' named entity 'FINDINGS' named entity 'EXPOSURE' named entity 'ANTIOXIDANT ACTIVITY' named entity 'APOPTOTIC' named entity 'TRE' named entity 'CAPACITY' named entity 'WORK' named entity 'CELLULAR MORPHOLOGY' named entity 'EFFECTIVE' named entity 'ANTIOXIDANT' named entity 'EXAMINING' named entity 'REDUCING' named entity 'PRIOR TO' named entity 'INJURY' named entity 'POSSESSED' named entity 'ITS'

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