About: Sensitivity and Specificity of Soluble Triggering Receptor Expressed on Myeloid Cells-1, Midregional Proatrial Natriuretic Peptide and Midregional Proadrenomedullin for Distinguishing Etiology and to Assess Severity in Community-Acquired Pneumonia

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About: Sensitivity and Specificity of Soluble Triggering Receptor Expressed on Myeloid Cells-1, Midregional Proatrial Natriuretic Peptide and Midregional Proadrenomedullin for Distinguishing Etiology and to Assess Severity in Community-Acquired Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sensitivity and Specificity of Soluble Triggering Receptor Expressed on Myeloid Cells-1, Midregional Proatrial Natriuretic Peptide and Midregional Proadrenomedullin for Distinguishing Etiology and to Assess Severity in Community-Acquired Pneumonia
Creator	Tenero, Laura Esposito, Susanna Principi, Nicola Corsini, Ilaria Zampiero, Alberto Villani, Alberto Cardinale, Fabio Sacco, Oliviero Baraldi, Eugenio Correra, Antonio Da Dalt, Liviana Dones, Piera Gambino, Monia Gangi, Maria Tovo, Pier
Source	Medline; PMC
abstract	STUDY DESIGN: This study aimed to evaluate the diagnostic accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), midregional proatrial natriuretic peptide (MR-proANP) and midregional proadrenomedullin (MR-proADM) to distinguish bacterial from viral community-acquired pneumonia (CAP) and to identify severe cases in children hospitalized for radiologically confirmed CAP. Index test results were compared with those derived from routine diagnostic tests, i.e., white blood cell (WBC) counts, neutrophil percentages, and serum C-reactive protein (CRP) and procalcitonin (PCT) levels. METHODS: This prospective, multicenter study was carried out in the most important children’s hospitals (n = 11) in Italy and 433 otherwise healthy children hospitalized for radiologically confirmed CAP were enrolled. Among cases for whom etiology could be determined, CAP was ascribed to bacteria in 235 (54.3%) children and to one or more viruses in 111 (25.6%) children. A total of 312 (72.2%) children had severe disease. RESULTS: CRP and PCT had the best performances for both bacterial and viral CAP identification. The cut-off values with the highest combined sensitivity and specificity for the identification of bacterial and viral infections using CRP were ≥7.98 mg/L and ≤7.5 mg/L, respectively. When PCT was considered, the cut-off values with the highest combined sensitivity and specificity were ≥0.188 ng/mL for bacterial CAP and ≤0.07 ng/mL for viral CAP. For the identification of severe cases, the best results were obtained with evaluations of PCT and MR-proANP. However, in both cases, the biomarker cut-off with the highest combined sensitivity and specificity (≥0.093 ng/mL for PCT and ≥33.8 pmol/L for proANP) had a relatively good sensitivity (higher than 70%) but a limited specificity (of approximately 55%). CONCLUSIONS: This study indicates that in children with CAP, sTREM-1, MR-proANP, and MR-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases, highlighting that PCT maintains the main role at this regard.
has issue date	2016-11-15(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0163262
bibo:pmid	27846213
has license	cc-by
sha1sum (hex)	4dd75f2cd80aa8704156923f916dd338bb88ab9b
schema:url	https://doi.org/10.1371/journal.pone.0163262
resource representing a document's title	Sensitivity and Specificity of Soluble Triggering Receptor Expressed on Myeloid Cells-1, Midregional Proatrial Natriuretic Peptide and Midregional Proadrenomedullin for Distinguishing Etiology and to Assess Severity in Community-Acquired Pneumonia
has PubMed Central identifier	PMC5113019
has PubMed identifier	27846213
schema:publication	PLoS One
resource representing a document's body	covid:4dd75f2cd80aa8704156923f916dd338bb88ab9b#body_text
is schema:about of	named entity 'natriuretic peptide' named entity 'levels' named entity 'test' named entity 'Cells' named entity 'Pneumonia' named entity 'SERUM' named entity 'COMPARED' named entity 'NEUTROPHIL' named entity 'CAP' named entity 'This' named entity 'C-reactive protein' named entity 'expressed' named entity 'bacterial' named entity 'Myeloid' named entity 'CAP' named entity 'C-reactive protein' named entity 'procalcitonin' named entity 'Receptor' named entity 'Etiology' named entity 'Natriuretic Peptide' named entity 'Sensitivity and Specificity' named entity 'procalcitonin' named entity 'bacteria' named entity 'apyrexia' named entity 'biomarker' named entity '2.6' named entity 'M. pneumoniae' named entity 'Turin' named entity 'WBC' named entity 'biomarker' named entity 'coronaviruses' named entity 'etiology' named entity 'fever' named entity 'clinical practice' named entity 'sTREM' named entity 'risk of death' named entity 'C-reactive protein' named entity 'Canada' named entity 'Craponne' named entity 'CAP' named entity 'respiratory rate' named entity '11.0' named entity 'etiology' named entity 'S. pneumoniae' named entity 'College Station' named entity 'infection' named entity 'CAP' named entity 'Italy' named entity 'atelectasis' named entity 'CAP' named entity 'alveolar' named entity 'blood levels' named entity 'RNA' named entity 'etiology' named entity 'experimental animal' named entity 'Mycoplasma pneumoniae' named entity 'viruses' named entity 'pediatricians' named entity 'etiology' named entity 'Pediatric' named entity 'missing data' named entity 'Biomarker' named entity 'pathogen' named entity 'CRP' named entity 'biomarker' named entity 'Receiver Operating Characteristic' named entity 'inflammation'

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