About: Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV-positive patients

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About: Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV-positive patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV-positive patients
Creator	Zhao, Min Huang, Lei Deng, Jianning Huang, Mr Lu, Xiangchan Wu, Fengyao Zhang, Naichun
Source	PMC
abstract	Arginase I (Arg I) and inducible nitric oxide synthase (iNOS) are important in regulating immune functions through their metabolites. Previous studies have revealed that the expression of Arg I is increased and the expression of iNOS is reduced in the serum and peripheral blood mononuclear cells of human immunodeficiency virus (HIV)-infected patients. As one of the most important immune organs and HIV replication sites, whether similar changes are present in the lymph nodes following HIV infection remains to be elucidated. To investigate this, the present study collected lymph node and blood specimens from 52 HIV-infected patients to measure the expression levels of Arg I and iNOS by immunohistochemistry and fluoresence-based flow cytometry. Compared with control subjects without HIV infection, the patients with HIV had significantly higher expression levels of Arg I in the lymph nodes and higher frequencies of Arg I(+) CD4(+) T cells and CD8(+) T cells in the blood and lymph nodes, and these results were contrary the those of iNOS in the corresponding compartments. The expression levels of Arg I in the lymph nodes and blood were negatively associated with peripheral CD4(+) T cell count and positively associated with viral load. However, the expression levels of iNOS in the lymph nodes and blood were positively associated with peripheral CD4(+) T cell count and negatively associated with viral load. These results showed that alterations in the expression levels of Arg I and iNOS in the peripheral T cells and peripheral nodes of HIV infected patients are associated with disease progression in these patients. These results indicate a potential to therapeutic strategy for delaying disease progression through regulating and manipulating the expression levels of Arg I and iNOS in patients infected with HIV.
has issue date	2015-11-23(xsd:dateTime)
bibo:doi	10.3892/mmr.2015.4601
bibo:pmid	26647762
has license	cc-by-nc-nd
sha1sum (hex)	4e0773d0ae56a69211b358144a99bbecbad56bac
schema:url	https://doi.org/10.3892/mmr.2015.4601
resource representing a document's title	Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV-positive patients
has PubMed Central identifier	PMC4686052
has PubMed identifier	26647762
schema:publication	Mol Med Rep
resource representing a document's body	covid:4e0773d0ae56a69211b358144a99bbecbad56bac#body_text
is schema:about of	named entity 'specimens' named entity 'iNOS' named entity 'manipulating' named entity 'collected' named entity 'patients' named entity 'expression' named entity 'nitric oxide synthase' named entity 'Expression' named entity 'ARGINASE' named entity 'EXPRESSION' named entity 'TO INVESTIGATE' named entity 'HIGHER' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'TO MEASURE' named entity 'INDUCIBLE NITRIC OXIDE SYNTHASE' named entity 'SIMILAR' named entity 'NODES' named entity 'COLLECTED' named entity 'T CELL' named entity 'FOLLOWING' named entity 'SERUM' named entity 'SUBJECTS' named entity 'ORGANS' named entity 'STUDY' named entity 'ONE OF' named entity 'STUDIES' named entity 'INCREASED' named entity 'PATIENTS' named entity 'INOS' named entity 'POSITIVE' named entity 'PERIPHERAL BLOOD' named entity 'EXPRESSION' named entity 'HIV' named entity 'FLOW CYTOMETRY' named entity 'PERIPHERAL' named entity 'METABOLITES' named entity 'DISEASE PROGRESSION' named entity 'INDUCIBLE NITRIC OXIDE SYNTHASE' named entity 'PATIENTS' named entity 'ARG' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'SPECIMENS' named entity 'EXPRESSION OF INOS' named entity 'LEVELS' named entity 'LYMPH NODES' named entity 'COMPARTMENTS' named entity 'IMPORTANT' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'IMMUNE' named entity 'HIV INFECTION' named entity 'COMPARED' named entity 'BLOOD' named entity 'HIV' named entity 'THESE' named entity 'ALTERATIONS' named entity 'ASSOCIATED WITH' named entity 'INFECTED' named entity 'LYMPH NODE' named entity 'LYMPH NODES' named entity 'CD8' named entity 'PRESENT' named entity 'POTENTIAL' named entity 'REGULATING' named entity 'SITES' named entity 'PREVIOUS' named entity 'CD4' named entity 'REDUCED' named entity 'REVEALED' named entity 'THERAPEUTIC' named entity 'CELL COUNT' named entity 'FREQUENCIES' named entity 'FUNCTIONS' named entity 'REPLICATION' named entity 'T CELLS' named entity 'HAVE'

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