About: A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion

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About: A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion
Creator	King, Malcolm Zayas, Gustavo Dimitry, John Zayas, Ana O'brien, Darryl
source	Medline; PMC
abstract	BACKGROUND: Infectious respiratory diseases are transmitted to non-infected subjects when an infected person expels pathogenic microorganisms to the surrounding environment when coughing or sneezing. When the airway mucus layer interacts with high-speed airflow, droplets are expelled as aerosol; their concentration and size distribution may each play an important role in disease transmission. Our goal is to reduce the aerosolizability of respiratory secretions while interfering only minimally with normal mucus clearance using agents capable of increasing crosslinking in the mucin glycoprotein network. METHODS: We exposed mucus simulants (MS) to airflow in a simulated cough machine (SCM). The MS ranged from non-viscous, non-elastic substances (water) to MS of varying degrees of viscosity and elasticity. Mucociliary clearance of the MS was assessed on the frog palate, elasticity in the Filancemeter and the aerosol pattern in a %22bulls-eye%22 target. The sample loaded was weighed before and after each cough maneuver. We tested two mucomodulators: sodium tetraborate (XL%22B%22) and calcium chloride (XL %22C%22). RESULTS: Mucociliary transport was close to normal speed in viscoelastic samples compared to non-elastic, non-viscous or viscous-only samples. Spinnability ranged from 2.5 ± 0.6 to 50.9 ± 6.9 cm, and the amount of MS expelled from the SCM increased from 47 % to 96 % adding 1.5 μL to 150 μL of XL %22B%22. Concurrently, particles were inversely reduced to almost disappear from the aerosolization pattern. CONCLUSION: The aerosolizability of MS was modified by increasing its cohesivity, thereby reducing the number of particles expelled from the SCM while interfering minimally with its clearance on the frog palate. An unexpected finding is that MS crosslinking increased %22expectoration%22.
has issue date	2005-09-02(xsd:dateTime)
bibo:doi	10.1186/1471-2466-5-11
bibo:pmid	16138926
has license	cc-by
sha1sum (hex)	4e1a080ea558bba7654e05d59ed0b6c6e686b66e
schema:url	https://doi.org/10.1186/1471-2466-5-11
resource representing a document's title	A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion
has PubMed Central identifier	PMC1208914
has PubMed identifier	16138926
schema:publication	BMC Pulm Med
resource representing a document's body	covid:4e1a080ea558bba7654e05d59ed0b6c6e686b66e#body_text
is schema:about of	named entity 'sneezing' named entity 'infected' named entity 'crosslinking' named entity 'glycoprotein' named entity 'secretions' named entity 'Our' named entity 'INCREASING' named entity 'INFECTIOUS' named entity 'CAPABLE' named entity 'PLAY' named entity 'GLYCOPROTEIN NETWORK' named entity 'COUGHING' named entity 'TRANSMITTED' named entity 'CONCENTRATION' named entity 'INFECTED' named entity 'ENVIRONMENT' named entity 'HIGH' named entity 'SNEEZING' named entity 'MUCUS LAYER' named entity 'NON-INFECTED' named entity 'MUCIN' named entity 'THEIR' named entity 'SURROUNDING' named entity 'PATHOGENIC' named entity 'RESPIRATORY DISEASES' named entity 'INTERFERING' named entity 'ROLE' named entity 'BACKGROUND' named entity 'RESPIRATORY HYGIENE' named entity 'CROSSLINKING' named entity 'SPEED' named entity 'RESPIRATORY' named entity 'INCREASING' named entity 'AEROSOL' covid:arg/4e1a080ea558bba7654e05d59ed0b6c6e686b66e named entity 'AIRWAY' named entity 'AIRFLOW' named entity 'SUBJECTS' named entity 'REDUCE' named entity 'BMC' named entity 'COUGH' named entity 'AIRWAY' named entity 'NEW' named entity 'AEROSOL' named entity 'PARADIGM' named entity 'SECRETIONS' named entity 'PULMONARY MEDICINE' named entity 'DISEASE TRANSMISSION' named entity 'CLEARANCE' named entity 'SIZE DISTRIBUTION' named entity 'TO REDUCE' named entity 'MUCUS' named entity 'IMPORTANT' named entity 'SECRETIONS' named entity 'DISPERSION' named entity 'INTERACTION' named entity 'PERSON' named entity 'GOAL' named entity 'MICROORGANISMS' named entity 'OUR' named entity 'NORMAL' named entity 'USING' named entity 'mucus' named entity 'subjects' named entity 'pathogenic' named entity 'expelled' named entity 'expels' named entity 'mucin' named entity 'airway' named entity 'Pulmonary Medicine' named entity 'first-line' named entity 'mucus' named entity 'viscoelastic' named entity 'body temperature' named entity 'mucus' named entity 'divalent' named entity 'infection'

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