About: Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis
Creator	Wu, Jing Yue, Ming Dong, Chen Cai, Weihua Sun, Xiaohua Jing, Yang Shao, Jianguo Xue, Hong Zhang, Jingqi
source	Medline; PMC
abstract	Hypertension is a common comorbidity in COVID-19 patients. However, the association of hypertension with the severity and fatality of COVID-19 remain unclear. In the present meta-analysis, relevant studies reported the impacts of hypertension on SARS-CoV-2 infection were identified by searching PubMed, Elsevier Science Direct, Web of Science, Wiley Online Library, Embase and CNKI up to 20 March 2020. As the results shown, 12 publications with 2389 COVID-19 patients (674 severe cases) were included for the analysis of disease severity. The severity rate of COVID-19 in hypertensive patients was much higher than in non-hypertensive cases (37.58% vs 19.73%, pooled OR: 2.27, 95% CI: 1.80–2.86). Moreover, the pooled ORs of COVID-19 severity for hypertension vs. non-hypertension was 2.21 (95% CI: 1.58–3.10) and 2.32 (95% CI: 1.70–3.17) in age <50 years and ⩾50 years patients, respectively. Additionally, six studies with 151 deaths of 2116 COVID-19 cases were included for the analysis of disease fatality. The results showed that hypertensive patients carried a nearly 3.48-fold higher risk of dying from COVID-19 (95% CI: 1.72–7.08). Meanwhile, the pooled ORs of COVID-19 fatality for hypertension vs. non-hypertension was 6.43 (95% CI: 3.40–12.17) and 2.66 (95% CI: 1.27–5.57) in age <50 years and ⩾50 years patients, respectively. Neither considerable heterogeneity nor publication bias was observed in the present analysis. Therefore, our present results provided further evidence that hypertension could significantly increase the risks of severity and fatality of SARS-CoV-2 infection.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1017/s095026882000117x
bibo:pmid	32460927
has license	cc-by
sha1sum (hex)	4e3d924a9e0cb76e95f18451940b15db9b38dce1
schema:url	https://doi.org/10.1017/s095026882000117x
resource representing a document's title	Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis
has PubMed Central identifier	PMC7270484
has PubMed identifier	32460927
schema:publication	Epidemiol Infect
resource representing a document's body	covid:4e3d924a9e0cb76e95f18451940b15db9b38dce1#body_text
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