About: Molecular Diagnosis of Severe Acute Respiratory Syndrome The State of the Art

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Diagnosis of Severe Acute Respiratory Syndrome The State of the Art
Creator	Mahony, James Richardson, Susan
Source	Elsevier
abstract	Severe acute respiratory syndrome (SARS) first appeared in Guangdong Province, China, in November 2002. Although virus isolation and serology were useful early in the SARS outbreak for diagnosing new cases, these tests are not generally useful because virus culture requires a BSL-3 laboratory and seroconversion is often delayed until 2 to 3 weeks after infection. The first qualitative reverse transcriptase-polymerase chain reaction tests for SARS-coronavirus (CoV) were sensitive and capable of detecting 1 to 10 genome equivalents. These assays were quickly supplemented with quantitative real-time assays that helped elucidate the natural history of SARS, particularly the initial presence of low viral loads in the upper respiratory tract and high viral loads in the lower respiratory tract. The unique natural history of SARS-CoV infection dictates the testing of both respiratory and nonrespiratory specimens, the testing of multiple specimens from the same patient, and sending out positives to be confirmed by a reference laboratory. Commercially available reverse transcriptase-polymerase chain reaction tests for SARS have recently appeared; however, meaningful evaluations of these assays have not yet been performed and their true performance has not been determined. These and other issues related to diagnosis of SARS-CoV infection are discussed in this review.
has issue date	2005-11-30(xsd:dateTime)
bibo:doi	10.1016/s1525-1578(10)60587-9
has license	els-covid
sha1sum (hex)	4e8306655e7f3c6ae88db9708a400ab78c011700
schema:url	https://doi.org/10.1016/s1525-1578%2810%2960587-9
resource representing a document's title	Molecular Diagnosis of Severe Acute Respiratory Syndrome The State of the Art
schema:publication	The Journal of Molecular Diagnostics
resource representing a document's body	covid:4e8306655e7f3c6ae88db9708a400ab78c011700#body_text
is schema:about of	named entity 'ART' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'STATE' named entity 'REVIEW' named entity 'MOLECULAR DIAGNOSIS' named entity 'Severe Acute Respiratory Syndrome' named entity 'primers' named entity 'SARS-CoV' named entity 'sensitivity and specificity' named entity 'SARS-CoV' named entity 'BSL-3' named entity 'viral load' named entity 'internal control' named entity 'RNA' named entity 'lower respiratory tract' named entity 'superspreading events' named entity 'SARS' named entity 'bronchoalveolar lavage' named entity 'gene' named entity 'primers' named entity 'coronavirus' named entity 'Hong Kong' named entity 'Germany' named entity 'RNA' named entity 'SARS' named entity 'Hong Kong' named entity 'SARS' named entity 'viruses' named entity 'pneumonia' named entity 'SARS' named entity 'SARS-CoV' named entity 'infection' named entity 'avian influenza virus' named entity 'SARS-CoV' named entity 'gene' named entity 'watery diarrhea' named entity 'PCR' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'antibodies' named entity 'TaqMan' named entity 'SARS' named entity 'Hamburg' named entity 'virus' named entity 'upper respiratory tract' named entity 'SARS-CoV' named entity 'HKU1' named entity 'SARS-CoV' named entity 'PCR' named entity 'RT-PCR' named entity 'lower respiratory tract' named entity 'N95' named entity 'RNA genome' named entity 'swine' named entity 'Germany' named entity 'genome' named entity 'enveloped viruses' named entity 'China' named entity 'BSL-2' named entity 'staff infection' named entity '2.2' named entity 'virus' named entity 'evolution' named entity 'intubation' named entity 'CoV' named entity 'epidemic' named entity 'gene' named entity 'intensive care unit' named entity 'postmortem' named entity 'China' named entity 'Guangdong' named entity 'Virus' named entity 'seroconversion' named entity 'replicase' named entity 'SARS' named entity 'virus' named entity 'lower respiratory tract' named entity 'Viral load' named entity 'interspecies transmission' named entity 'Hong Kong' named entity 'fomites' named entity 'Coronaviridae' named entity 'RT-PCR'

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