About: Evolution of vertebrate interferon inducible transmembrane proteins

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About: Evolution of vertebrate interferon inducible transmembrane proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evolution of vertebrate interferon inducible transmembrane proteins
Creator	Frankenberg, Stephen Hickford, Danielle Shaw, Geoff Renfree, Marilyn
Source	Medline; PMC
abstract	BACKGROUND: Interferon inducible transmembrane proteins (IFITMs) have diverse roles, including the control of cell proliferation, promotion of homotypic cell adhesion, protection against viral infection, promotion of bone matrix maturation and mineralisation, and mediating germ cell development. Most IFITMs have been well characterised in human and mouse but little published data exists for other animals. This study characterised IFITMs in two distantly related marsupial species, the Australian tammar wallaby and the South American grey short-tailed opossum, and analysed the phylogeny of the IFITM family in vertebrates. RESULTS: Five IFITM paralogues were identified in both the tammar and opossum. As in eutherians, most marsupial IFITM genes exist within a cluster, contain two exons and encode proteins with two transmembrane domains. Only two IFITM genes, IFITM5 and IFITM10, have orthologues in both marsupials and eutherians. IFITM5 arose in bony fish and IFITM10 in tetrapods. The bone-specific expression of IFITM5 appears to be restricted to therian mammals, suggesting that its specialised role in bone production is a recent adaptation specific to mammals. IFITM10 is the most highly conserved IFITM, sharing at least 85% amino acid identity between birds, reptiles and mammals and suggesting an important role for this presently uncharacterised protein. CONCLUSIONS: Like eutherians, marsupials also have multiple IFITM genes that exist in a gene cluster. The differing expression patterns for many of the paralogues, together with poor sequence conservation between species, suggests that IFITM genes have acquired many different roles during vertebrate evolution.
has issue date	2012-04-26(xsd:dateTime)
bibo:doi	10.1186/1471-2164-13-155
bibo:pmid	22537233
has license	cc-by
sha1sum (hex)	4e9aa1aef7efca6b41b1503135145e0dd75a39ce
schema:url	https://doi.org/10.1186/1471-2164-13-155
resource representing a document's title	Evolution of vertebrate interferon inducible transmembrane proteins
has PubMed Central identifier	PMC3424830
has PubMed identifier	22537233
schema:publication	BMC Genomics
resource representing a document's body	covid:4e9aa1aef7efca6b41b1503135145e0dd75a39ce#body_text
is schema:about of	named entity 'mediating' named entity 'Evolution' covid:arg/4e9aa1aef7efca6b41b1503135145e0dd75a39ce named entity 'Interferon' named entity 'species' named entity 'inducible' named entity 'mineralisation' named entity 'cell proliferation' named entity 'short-tailed opossum' named entity 'marsupial' named entity 'bone matrix' named entity 'phylogeny' named entity 'analysed' named entity 'phylogeny' named entity 'yolk sac' named entity 'tissue samples' named entity 'IFITM5' named entity 'gene' named entity 'Marsupials' named entity 'IFITM5' named entity 'mammals' named entity 'frog' named entity 'blue line' named entity 'Amino acid sequences' named entity 'paralogues' named entity 'IFITM3' named entity 'amino acid' named entity 'Promega' named entity 'IFITM5' named entity 'IFITM5' named entity 'Ifitm5' named entity 'PGCs' named entity 'IFITM5' named entity 'exons' named entity 'gene clusters' named entity 'FISH' named entity 'mammalian species' named entity 'genomes' named entity 'IFITM1' named entity 'mammalian species' named entity '3′ UTR' named entity 'intron' named entity 'orthologues' named entity 'phenotype' named entity 'IFITM5' named entity 'EST' named entity 'murine' named entity 'gene family' named entity 'eutherian' named entity 'IFITM1' named entity 'EST' named entity 'exon' named entity 'marsupial' named entity 'shRNA' named entity 'lizard' named entity 'opossum' named entity 'IFITM5' named entity 'gastrula' named entity 'IFITM5' named entity 'opossum' named entity 'Bony fish' named entity 'expression patterns' named entity 'IFITM5' named entity 'yolk sac' named entity 'IFITM5' named entity 'orthologues' named entity 'transcriptome' named entity 'IFITM5' named entity 'multi-sequence alignment' named entity 'zebrafish' named entity 'paralogues' named entity 'interferon' named entity 'Neighbour joining' named entity 'antibody' named entity 'embryo' named entity 'monotreme' named entity 'IFITM5' named entity 'zebrafish'

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