About: Frailty and mortality in hospitalized older adults with COVID-19: retrospective observational study

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About: Frailty and mortality in hospitalized older adults with COVID-19: retrospective observational study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Frailty and mortality in hospitalized older adults with COVID-19: retrospective observational study
Creator	De Smet, Robert Frans, Eric Frans, Johan Ho, Erwin Laurent, Michaël Lemahieu, Wim Lybeert, Peter Mellaerts, Bea Ombelet, Sara Smismans, Annick Symons, Rolf Vandewinckele, Hannelore
Source	Elsevier; Medline; PMC
abstract	ABSTRACT Objectives To determine the association between frailty and short-term mortality in older adults hospitalized for coronavirus disease 2019 (COVID-19). Design Retrospective single-center observational study. Setting and participants: N = 81 patients with COVID-19 confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR), at the Geriatrics department of a general hospital in Belgium. Measure ments: Frailty was graded according to the Rockwood Clinical Frailty Scale (CFS). Demographic, biochemical and radiological variables, co-morbidities, symptoms and treatment were extracted from electronic medical records. Results Participants (N = 48 women, 59%) had a median age of 85 years (range 65 – 97 years), median CFS score of 7 (range 2 – 9), and 42 (52%) were long-term care residents. Within six weeks, eighteen patients died. Mortality was significantly but weakly associated with age (Spearman r = 0.241, P = 0.03) and CFS score (r = 0.282, P = 0.011), baseline lactate dehydrogenase (LDH) (r = 0.301, P = 0.009), lymphocyte count (r = -0.262, P = 0.02) and RT-PCR cycle threshold (Ct, r = -0.285, P = 0.015). Mortality was not associated with long-term care residence, dementia, delirium or polypharmacy. In multivariable logistic regression analyses, CFS, LDH and RT-PCR Ct (but not age) remained independently associated with mortality. Both age and frailty had poor specificity to predict survival. A multivariable model combining age, CFS, LDH and viral load significantly predicted survival. Conclusions and implications Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID-19, if sufficient resources are available.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1016/j.jamda.2020.06.008
bibo:pmid	32674821
has license	els-covid
sha1sum (hex)	4ea4b1c1cf1da05f2a356941b28b397c0e728df8
schema:url	https://doi.org/10.1016/j.jamda.2020.06.008
resource representing a document's title	Frailty and mortality in hospitalized older adults with COVID-19: retrospective observational study
has PubMed Central identifier	PMC7280137
has PubMed identifier	32674821
schema:publication	J Am Med Dir Assoc
resource representing a document's body	covid:4ea4b1c1cf1da05f2a356941b28b397c0e728df8#body_text
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