About: Early-Morning vs Spot Posterior Oropharyngeal Saliva for Diagnosis of SARS-CoV-2 Infection: Implication of Timing of Specimen Collection for Community-Wide Screening

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About: Early-Morning vs Spot Posterior Oropharyngeal Saliva for Diagnosis of SARS-CoV-2 Infection: Implication of Timing of Specimen Collection for Community-Wide Screening Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Early-Morning vs Spot Posterior Oropharyngeal Saliva for Diagnosis of SARS-CoV-2 Infection: Implication of Timing of Specimen Collection for Community-Wide Screening
Creator	Sridhar, Siddharth Li, Xin Yuen, Kwok-Yung Lung, Kwok-Cheung Chan, Fuk-Woo, Jasper Liu, Wai-To To, Kai-Wang Yip, Yan Cheng, Chi-Chung Chik-, Cyril Fan-Ngai, Ivan Hung, Chiu, Kelvin Hei-Yeung Chung, Wai-Hin Kwan, Grace Sze-Wai Ling-Lung, Derek
source	Medline; PMC; WHO
abstract	BACKGROUND: Posterior oropharyngeal saliva is increasingly recognized as a valid respiratory specimen for SARS-CoV-2 diagnosis. It is easy to collect and suitable for community-wide screening. The optimal timing of collection is currently unknown, and we speculate that an early-morning specimen before oral hygiene and breakfast would increase the diagnostic yield. METHODS: Posterior oropharyngeal saliva was collected at 5 different time points within the same day from 18 patients with previously confirmed SARS-CoV-2 infection by molecular testing. Cycle threshold (Ct) values were compared. RESULTS: There was an overall trend of lower Ct values from specimens collected in the early morning, with a gradual decrease of viral load towards nighttime, but reaching statistical significance only when compared with the specimens collected at bedtime. Eight out of 13 subjects had a higher viral load in the early morning than the rest of the 4 time points (before lunch, before teatime at 3 pm, before dinner, before bedtime). CONCLUSIONS: The result suggests a diurnal variation of viral shedding from the upper respiratory tract with a trend showing higher viral load in the early morning. For community screening purposes, posterior oropharyngeal saliva could be taken throughout the day, but preferably in the early morning to maximize the yield.
has issue date	2020-06-07(xsd:dateTime)
bibo:doi	10.1093/ofid/ofaa210
bibo:pmid	32577428
has license	cc-by-nc-nd
sha1sum (hex)	4eb7174618f76ee75921a294ba3853fd5e8c3914
schema:url	https://doi.org/10.1093/ofid/ofaa210
resource representing a document's title	Early-Morning vs Spot Posterior Oropharyngeal Saliva for Diagnosis of SARS-CoV-2 Infection: Implication of Timing of Specimen Collection for Community-Wide Screening
has PubMed Central identifier	PMC7299521
has PubMed identifier	32577428
schema:publication	Open Forum Infect Dis
resource representing a document's body	covid:4eb7174618f76ee75921a294ba3853fd5e8c3914#body_text
is schema:about of	named entity 'breakfast' named entity 'SARS-CoV-2' named entity 'screening' named entity 'oropharyngeal' named entity 'screening tests' named entity '3 pm' named entity 'lung' named entity 'viral particles' named entity 'probability' named entity 'nosocomial' named entity 'oropharynx' named entity 'oropharyngeal' named entity 'Department of Microbiology' named entity 'infection' named entity 'contact tracing' named entity 'coughing' named entity 'reverse transcription polymerase chain reaction' named entity 'statistically significant' named entity 'oropharyngeal' named entity 'oral cavity' named entity 'viral load' named entity 'infection' named entity 'sputum' named entity 'asymptomatic infection' named entity 'SARS-CoV-2' named entity 'contact tracing' named entity 'ageusia' named entity 'alveoli' named entity 'headache' named entity 'sputum' named entity 'saliva' named entity 'sputum' named entity 'nasopharyngeal aspirate' named entity 'molecular testing' named entity 'comorbidities' named entity 'viral load' named entity 'oropharyngeal' named entity 'saliva' named entity 'SARS-CoV-2' named entity 'Ruttonjee Hospital' named entity 'productive cough' named entity 'saliva' named entity 'SARS-CoV-2' named entity 'aerosol' named entity 'small airways' named entity 'Infectious Diseases' named entity 'oropharyngeal' named entity 'oropharynx' named entity 'cough' named entity 'Mycobacterium tuberculosis' named entity 'ANOVA' named entity 'oropharyngeal' named entity 'sputum' named entity 'alveolar cells' named entity 'mycobacteria' named entity 'infection' named entity 'saliva' named entity 'World Health Organization' named entity 'HKSAR' named entity 'tuberculosis' named entity 'oropharyngeal' named entity 'saliva' named entity 'dry cough' named entity 'saliva' named entity 'virus infection'

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